台湾国際口唇口蓋裂医師研究プログラム
胎児の超音波診断から分娩の治療まで
口唇口蓋裂医師研究プログラムについて
本計画は2022年より本格始動へ
2017年12月より台北医学大学頭蓋顔面センター（クラニオフェイシャルセンター）所属医師・陳国鼎の医療チームと台湾において出生前診断の権威である台児診所（台児クリニック）が提携し、「胎児口唇口蓋裂共同診療」を開始しました。
台児クリニックにて胎児スクリーニング専門医が口唇口蓋裂のタイプと程度を精確に診断した後、ご家族に向けて子どもの出生後の治療計画と予後を整形外科の医療チームが精確且つ完全に説明をすることによって、ご家族の考えや判断の手助けをし、疾患を持った胎児が生まれた後ご家族が心身ともに受けるショックを和らげることに役立ちます。
両者が提携してから4年となりました口唇口蓋裂共同診療カウンセリングのモデルは国家品質標章（Symbol of National Quality）の認証を取得するにとどまらず、台湾における口唇口蓋裂医療のロールモデルとも称されています。
本計画は交流学習の方法を奨励しており、胎児顔面異常の診断及び治療に従事する海外の先生など有志の方々を招待して研修を行い、国際社会へ向けて善意でお応えするため、完全なトレーニング計画を通じて、台湾の革新的な顔面医療の技術及び経験を共有しています。
COVID-19新型コロナウイルスが蔓延する中、台湾はアメリカ、日本、リトアニア、スロバキア、チェコ、ポーランドなど6か国からワクチンを寄贈していただき、多くの国々が互いに協力し助け合う友情を目にしました。私達も間接的ではありますが、世界へ向けて善意の力で、世界各地の顔面異常の疾患を持つご家庭を手助けし、友好国の方々と医療協力の関係を深めていきたいと思っています。
口唇口蓋裂国際研修医師の歩み
2018年1月、各国の研究医が台北医学大学附属病院（Taipei Medical University Hospital）にて陳国鼎医師から口唇口蓋裂の手術及び関連知識を学びました。
写真：左からDorte Ohrmann（ドイツ）、陳国鼎医師、April LS Wong（マレーシア）、Paa Ekow Hoyte-Williams（ガーナ）
2019年12月、イタリアの医師が若い医師を帯同し、短期間で口唇口蓋裂の手術及び関連知識を学びました。
写真：イタリア・ミランのDr.Autelitano医師（左から2人目）
2023 國際口唇口蓋裂国際研修医師プログラム 森田皓貴医師研修動画
口唇口蓋裂の出生前診断と出生後の治療チーム
台児クリニックによる口唇口蓋裂共同診療の状況：
胎児口唇口蓋裂に長けた産婦人科医、頭蓋顎顔面外科医、臨床連携師、専門の超音波検査技師及びケースマネージャーが協力し、胎児が口唇口蓋裂である妊婦に対して出生前診断とカウンセリングを行っています。
一列目：楊子逸医師
二列目左から：陳国鼎医師、李文車医師
三列目左から：蔡宛祐臨床連携師、王儒萱看護師、李佳恆超音波検査技師
台北医学大学附属病院頭蓋顔面センターチーム集合写真
1列目左から：鍾麗英看護師長、黄郁理医師、陳国鼎医師、蔡宛祐連携士、朱欣蘭看護師長
2列目左から：施潔瑜副主任、李佳穎看護師、潘褘琳専門看護師、Lucia Pannuto医師、朱詠琳専門看護師、李昕緯看護師、王虹文研究補助員
台北医学大学附属病院頭蓋顔面センターチームと台児クリニック胎児頭蓋顔面奇形ワークグループ
2020年「第12回台児胎児医学ワークショップ」会場記念写真
1列目左から：李佳恆超音波検査技師、黄宇鋭医師、陳国鼎医師、李琇菁言語聴覚士、王儒萱医師、蔡宛祐連携士、潘褘琳看護師、林哲玄医師
2列目左から：蘇婉婷超音波検査技師、張東曜医師、楊子逸医師、李文車医師、王儒萱看護師、葛萱超音波検査技師。
台児クリニック
楊子逸医師
楊子逸医師
南投埔里キリスト教病院
李文車医師
李文車医師
台児クリニック
王儒萱看護師
王儒萱看護師
台児クリニック
李佳恆超音波検査技師
李佳恆超音波検査技師
台児クリニック
夏敬淇超音波検査技師
夏敬淇超音波検査技師
胎児口唇口蓋裂の活動の歩み
口唇口蓋裂父母サポートワークショップ
陳国鼎医師が主導し、口唇口蓋裂の胎児の父母となる方々が子どもと親子の成長ワークショップに参加しました。
命の体験を振り返ったり、ボランティアのお母さん同士での交流や経験、看護のカウンセリングやお世話のコツなどの話題を共有することを通じて、妊婦さんやそのご家族が感じる出生前の焦りを軽減し、更に高品質なケアを提供し、ご家族に寄り添いながら一緒に赤ちゃんを迎えます。
胎児口唇口蓋裂出生前から出生後までのケア認証課程
口唇口蓋裂の新生児に関して、受け入れがたいことといえば、月子中心（産後ケアセンター）或いは保育システムのケア能力不足により、口唇口蓋裂の赤ちゃんのケアサービスを拒絶されてしまうということです。
台湾胎児医学振興会と陳国鼎医師はこの課程を特別に開設しました。
専門的なケアをする従事者（産後ケアの看護師や保育士）に口唇口蓋裂に関する知識を深めてもらい、どのように口唇口蓋裂の赤ちゃんのお世話をするのかを認知してもらいます。
そうすることで口唇口蓋裂の赤ちゃんがいるお母さんとお父さんに一息つく機会を提供できます。
2020.10.31 （Activity record）
2021.03.13（Activity record）
2021.10.17（Activity record）
2021.12.18（Activity record）
口唇口蓋裂産後ケア関連書籍
ウサギちゃんよく大きくなぁれ―口唇口蓋裂の治療手帳
出版日：2020/9
監修：陳国鼎、張東曜、李文車
著者：楊子逸、陳彦妮、李佳恆、蘇婉婷、王儒萱
この本は写真・図表をふんだんに盛り込み、口唇口蓋裂の各タイプや治療について紹介している台湾初の参考書です。出生前と出生後においてお父さんとお母さんに赤ちゃんの出生後の顔貌やケア、治療の過程などをよりわかりやすく紹介しています。
口唇口蓋裂産後の攻略本（口蓋裂の治療手帳）
出版予定日：2022/1
監修：陳国鼎、張東曜
製作チーム：
台児クリニック胎児頭蓋顔面奇形ワークグループ（楊子逸医師、王儒萱看護師）
台北医学大学附属病院頭蓋顔面センター医療チーム（陳国鼎医師、潘褘琳看護師、蔡暁倩医師、林哲玄医師、陳姵璇医師、李琇菁言語聴覚士、曽頌恵医師、黄宇鋭医師、蔡宛祐連携士）
この本は口唇口蓋裂のお子さんを育んでいるご家庭には必見の本です。主に口唇口蓋裂のお子さんがいるご家庭への提案、出生前診断から産後の治療までよくある問題などを完全網羅した本になります！
関連ニュースへのリンク
計画主催者（ホスト）
陳國鼎
Philip Kuo-Ting Chen M.D.
Plastic Surgery
E-mail： philip.ktchen@gmail.com
学歴：
1974-1981国立台湾大学医学部
医学専門分野：
頭蓋顔面再建
口唇口蓋裂
口蓋裂の手術
児童の整形
整形美容
自身の身体からの脂肪注入（脂肪移植）
学歴：
1974-1981国立台湾大学医学部
医学専門分野：
頭蓋顔面再建
口唇口蓋裂
口蓋裂の手術
児童の整形
整形美容
自身の身体からの脂肪注入（脂肪移植）
Postgraduate Training and Past Positions：
July 1980 – June 1981 Internship, National Taiwan University Hospital
July 1981 – June 1984 Residency in General Surgery, Veterans General Hospital, Taipei
July 1984 – June 1986 Residency in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1986 – June 1987 Senior Resident in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1987 – June 1990 Attending Staff in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1990 – June 1991 Clinical Fellow in Craniofacial Surgery, Hospital for Sick Children & University of Toronto, Toronto, Canada
July 1991 – April 1996 Attending Staff in Plastic Surgery,Craniofacial Surgery & Pediatric Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Feb 1992 – July 1993 Instructor in Surgery, Chang Gung Memorial Hospital
July 1993 – July 1997 Assistant Professor in Surgery, Chang Gung Memorial Hospital
April 1996 – Aug 2002 Director of Pediatric Plastic Surgery, Chang Gung Children's Hospital, Taoyuan, Taiwan
July 1997 – July 2011 Associate Professor in Surgery, Chang Gung Memorial Hospital
Aug 1997 – July 2003 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Apr 2000 – July 2006 Deputy-chief in surgery, Chang Gung Children’s Hospital, Taoyuan
Nov 1998 – Nov 2006 Council member in the Asian Pacific Craniofacial Association
Jan 2001 – Feb 2007 President, Taiwan Cleft Palate-Craniofacial Association
Nov 2003 – July 2007 Vice Chairman, Department of Plastic & Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei
Dec 2004 – Nov 2008 Council member, Plastic Surgery Association, ROC
Nov 2006 – Oct 2008 President, Asian Pacific Craniofacial Association
Dec 2006 – Dec 2010 Council member, Taiwan Society of Aesthetic & Plastic Surgery
May 2006 – May 2014 National secretary for Chinese Taipei in International Society of Aesthetic Plastic Surgery
July 2006 – June 2014 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei & Taoyuan
Aug 2011 – June 2017 Board member, Asian Pacific Region, AOCMF
July 2011 – Sep 2017 Professor in Surgery, Chang Gung Memorial Hospital
Jan 2012 – Sep 2017 Director, Craniofacial center, Chang Gung Memorial Hospital, Taoyuan
Jun 2007 – May 2019 Medical Advisory Board, The Smile Train
Present Position：
Apr 2000 – Present Board member, Noordhoff Craniofacial Foundation
Feb 2007 – present Council member, Taiwan Cleft Palate –Craniofacial Association
Oct 2017 – Present Director, Craniofacial Center, Taipei Medical University Hospital
Professional Affiliation：
Surgical Association, Taiwan.
Plastic Surgery Association, Taiwan.
Taiwan Cleft Palate-Craniofacial Association
American Cleft Palate-Craniofacial Anomaly Association
Taiwan Society of Aesthetic & Plastic Surgery
Asian Pacific Craniofacial Surgical Association
Clinical Interests：
Craniofacial surgery
Cleft lip/palate
Pediatric plastic surgery
Facial cosmetic surgery
Researches：
1.NSC88-2314-B-182A-016, 1998-1999 – An animal Model in Experimental Studies of Maxillary Growth after Palatoplasty under Microscopic Magnification.
2.CMRP774 – The Effect of the Residual Alveolar Cleft on the Nasal Structure and Physiology in Cleft Patients.
3.NSC89-2314-B-182-098 – Assessment of Lip Function after Lip Repair (Co-investigator)
4.NSC90-2320-B-182A-00, 2001-2003 – Genetic epidemiologic study on oral clefts by association and transmission disequilibrium test in Taiwan. (Co-investigator)
5.NSC90-2212-E-008-025, 2001-2002 – A computer-assisted simulation, planning and navigation system for craniofacial reconstructive and plastic surgery. (Co-investigator)
6.NSC90-2212-E-182A-001, 2001-2003 – The design and fabrication of defect implants, planning and simulation of craniofacial reconstruction.
7.NSC91-2314-B-182A-119, 2002-2003 – Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial
8.NSC92-2314-B-182A-173, 2003-2004 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (1)
9.NSC93-2314-B-182A-020,2004-2005 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (2)
10.NSC95-2314-B-182A-043, 2006-2007 – Sensory recovery after facial bone injury
11.NIH grant R01 DE014581-01A1, 2004-2008 – International genetic epidemiology of oral clefts. (Co-investigator)
12.SMRPG34002, 2004-2006 – Clinical manifestation and biomedical study on neurofibromatosis. (Co-investigator)
13.SQCP01 – A controlled randomized study for the speech and growth outcome between two different timing and techniques of cleft palate repair.
14.CMRPG390731, 2010-2013 – Botulinum toxin to improve results in cleft lip repair
15.CMRPG390721, 2010-2013 -- Long term comparison of two nasoalveolar molding techniques in complete unilateral cleft lip patients
16.CMRPG590011, 2010-2013 -- Morphological change of chest wall after harvesting the costal cartilage. (Co-investigator)
17.CMRPG5C0111, 2013-2014 -- Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial. (Co-investigator)
18. CMRPG5C0101, 2013-2014 -- The establishment of an integrated database on oral clefts. (Co-investigator)
19.CMRPG5C0121, 2013-2014 -- Stability of One-piece versus Two-piece Le Fort I Osteotomy: A Prospective Study. (Co-investigator)
20. CRRPG5C0131, 2013-2014 -- Comparative Outcomes of Alveolar Bone Grafting versus Gingivoperiosteoplasty at the Time of Le Fort I Osteotomy: A Prospective Randomized Trial. (Co-investigator)
21.CRRPG5C0141, 2013-2014 -- Inferior Alveolar Nerve Injury after Bilateral Sagittal Split Osteotomy in Oral Clefts. (Co-investigator)
22.CRRPG5C0071, 2014-2016 -- The impacts of Orthognathic Surgery on Speech and Velopharyngeal function of patients with Cleft Lip and Palate.
23. CRRPG5C0061, 2014-2016 -- Using clinical audiology to seek for related hearing changes following Orthognathic surgery in cleft patients. (Co-investigator)
24. CRRPG5C0051, 2014-2016 -- Airway Changes after Cleft Orthognathic Surgery Evaluated by Three Dimensional Computed Tomography and Overnight Polysomnographic Study. (Co-investigator)
25. CRRPG5C0041, 2014-2016 -- The changes of periodontal tissues following orthognathic surgery in patients with unilateral cleft lip and palate. (Co-investigator)
26. CRRPG5C0031, 2014-2016 -- Post Operative Stability of Surgery First or Orthodontic First in Unilateral Cleft lip and Palate. (Co-investigator)
27. XMRPG1E0091, 2015-2016 -- BOTOX Treatment of Masseter Muscle Hypertrophy.
28. CMRPG5E0061, 2015-2016 -- Clinical evaluation of silicone gel in the treatment of cleft lip scars.(Co-investigator)
29. CMRPG5F0021, 2015-2016 -- The Use of New Designed Nasal Splint in the Primary Management of Unilateral Cleft Nasal Deformity.(Co-investigator)
30. CMRPG5F0061, 2016 – Craniofacial Risk Factors of Obstrctive Sleep Apnea Following Pharyngeal Flap for Secondary Velopharyngeal Insufficiency. (Co-investigator)
31. CMRPG3F0731, 2016-2017 -- The Effect of Botulinum Toxin to unilateral cleft lip scar and nostril width.
32. NMRPG5F0051, 2016-2017 – Long Term Comparison Study of Philtral Ridge Morphology with Two Different Techniques of Philtral Reconstruction. (Co-investigator)
33. NMRPG3F0471, 2016-2017 -- Botulinum Toxin for the prevention of widening of unilateral cleft lip nose.
34. 1789-301-008, 2019-2021 -- BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
35. 109-2314-B-038-035-, 110-2314-B-038 -168 -, 2020-2022 -- The evaluation and treatment of nasal obstruction in unilateral cleft lip and palate patients.
Honor & Award：
Best paper award: Philip KT Chen, J Wu, YR Chen, MS Noordhoff: Correction of secondary velopharyngeal insufficiency in cleft palate patients with Furlow palatoplasty. Plast Reconstr Surg 94:933, 1994. Best paper award for the American Society of Maxillofacial Surgery, 1995
Best paper award: Eric JW Liou, Philip KT Chen, CS Huang, YR Chen: Interdental Distraction Osteogenesis and Rapid Tooth Movement: A Novel Approach to Approximate a Wide Alveolar Cleft or Bony Defect: Plast Reconstr Surg 105(4): 1262, 2000. Best paper award for the American Society of Maxillofacial Surgery, 2001
Visiting expertise in the Expertise Course of Hong Kong Plastic Surgery Society. Hong Kong, Jan, 2001.
Visiting expertise for the Great Ormond Street Hospital for Children, Nov, 2003
“Millard’s Visiting Professor Oration” in 4th Annual Congress of the Indian Society of Cleft Lip, Palate and Craniofacial Anomalies, Hyderabad, India, 2005
Visiting professor, Jiaotung University, Xian, China, Apr, 2009
“Godrej visiting professor oration”. In Annual meeting of the Association of Plastic surgeons of India, Chandigarh, India, 2014
Best paper award: CS Chang, CG Wallace, YC Hsiao, CJ Chang, PKT Chen: Botulinum Toxin to Improve Results in Cleft Lip Repair. Plast Reconstr Surg 134(3):511-516, 2014 (Corresponding author). PRS best paper award 2015.
“Best International Collaboration Paper-Gold, 2016” (PRS Global Open 3(3);e313, 2015: A Model Humanitarian Cleft Mission: 312 cleft surgeries in 7 days. GQ Fayyaz, NA Gill, I Ishaq, MA Ganatra, F Mahmood, M Kashif, I Alam, P KT Chen, LJ Lo, DR Laub)
張東曜
Tung-Yao Chang
台児クリニック創業者・院長
E-mail address： tychang@fetalmedicine.tw
Language：Chinese, English
学歴：
1995-1992 台北医学大学附属病院医学部学士
1998-1999 英国ノッティンガム大学人類発展学部産科超音波学修士
医学専門分野：
ハイリスク妊娠
胎児エコー
Clinical Training:
Residency, department of ob/gyn, Ministry of Health Taipei County Hospital, Taipei County, Taiwan, 1993-1994.
Residency, department of ob/gyn, Taipei Mackay Memorial Hospital, Taipei, Taipei, Taiwan, 1994-1998.
Joint advanced course in obstetric ultrasound of RCOG & RCR, Pregnancy Assessment Centre, Queen’s Medical Centre, Nottingham, UK, 1998-1999.
Clinical observer, Harris Birthright Foetal Medicine Centre, King’s College London, UK, 1999
Fellowship, department of high risk pregnancy, Taipei Mackay Memorial Hospital, Taipei, Taiwan, 1999-2001
Current Position:
Founder and doctor, Taiji Clinic, from 2008
Publication ：
Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Chen CP, Chern SR, Shih JC, Wang W, Yeh LF, Chang TY, Tzen CY. Prenat Diagn. 2001 Feb;21(2):89-95.
Prenatal diagnosis of de novo distal 11q deletion associated with sonographic findings of unilateral duplex renal system, pyelectasis and orofacial clefts. Chen CP, Chern SR, Tzen CY, Lee MS, Pan CW, Chang TY, Wang W. Prenat Diagn. 2001 Apr;21(4):317-20.
Prenatal diagnosis of partial monosomy 18p(18p11.2-->pter) and trisomy 21q(21q22.3-- >qter) with alobar holoprosencephaly and premaxillary agenesis. Chen CP, Chern SR, Wang W, Lee CC, Chen WL, Chen LF, Chang TY, Tzen CY. Prenat Diagn. 2001 May; 21(5):346-50. Review.
Resolution of fetal bilateral chylothorax and ascites after two unilateral thoracocenteses. Chen CP, Chang TY, Wang W. Ultrasound Obstet Gynecol. 2001 Oct;18(4):401-2.
Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome. Chen CP, Sheu JC, Wang W, Lin SP, Chang TY, Tzen CY. Prenat Diagn. 2002 Feb;22(2):166.
Sonographic appearance of the uterus after simple square suturing for rapid control of postpartum hemorrhage and preservation of fertility. Chen CP, Chang TY, Yeh LF, Lin CJ, Wang W. J Clin Ultrasound. 2002 Mar-Apr;30(3):189-91.
Sonographic detection of situs inversus, ventricular septal defect, and short-rib polydacty-ly syndrome type III (Verma-Naumoff) in a second-trimester fetus not known to be at risk. Chen CP, Chang TY, Tzen CY, Lin CJ, Wang W. Ultrasound Obstet Gynecol. 2002 Jun;19(6):629-31.
Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb- body wall complex. Chen CP, Tzen CY, Chang TY, Yeh LF, Wang W. Ultrasound Obstet Gynecol. 2002 Jul;20(1):94-5.
Second trimester molecular diagnosis of a stop codon FGFR3 mutation in a type I thanatophoric dysplasia fetus following abnormal ultrasound findings. Chen CP, Chern SR, Chang TY, Lin CJ, Wang W, Tzen CY. Prenat Diagn. 2002 Aug;22(8):736-7.
Perinatal imaging findings of inherited Sotos syndrome. Chen CP, Lin SP, Chang TY, Chiu NC, Shih SL, Lin CJ, Wang W, Hsu HC. Prenat Diagn. 2002 Oct;22(10):887-92.
Prenatal diagnosis of partial trisomy 3p and partial monosomy 11q in a fetus with a Dandy-Walker variant and trigonocephaly. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Town DD, Chen LF, Lee MS. Prenat Diagn. 2002 Dec;22(12):1112-3.
Prenatal diagnosis of the Dandy-Walker malformation and ventriculomegaly associated with partial trisomy 9p and distal 12p deletion. Chen CP, Chang TY, Shih JC, Lin SP, Lin CJ, Wang W, Lee CC, Town DD, Pan CW, Tzen CY. Prenat Diagn. 2002 Dec;22(12): 1063-6.
Prenatal diagnosis of mosaic ring chromosome 22 associated with cardiovascular abnor- malities and intrauterine growth restriction. Chen CP, Chern SR, Chang TY, Lee CC, Chen LF, Tzen CY, Wang W, Lin CJ, Yang BP, Yang LS. Prenat Diagn. 2003 Jan;23(1): 40-3.
Prenatal diagnosis of de novo mosaic distal 18q deletion associated with congenital anomalies. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Chen LF, Chen WL. Ultrasound Obstet Gynecol. 2003 Feb;21(2):202-4.
Second-trimester sonographic detection of short rib-polydactyly syndrome type II (Majewski) following an abnormal maternal serum biochemical screening result. Chen CP, Chang TY, Tzen CY, Wang W. Prenat Diagn. 2003 Apr;23(4):353-5.
Early second-trimester diagnosis of monozygotic twins discordant for cystic hygroma col- li and Turner syndrome. Chen CP, Chang TY, Chern SR, Town DD, Pan CW, Lee MS, Wang W. Prenat Diagn. 2003 Apr;23(4):352-3.
Second-trimester sonographic demonstration of retrognathia and bilateral pyelectasis in a fetus with a duplication of chromosome 10q24.1—>qter. Chen CP, Chang TY, Tzen CY, Wang W, Lee CC, Chen LF, Lee MS, Lin SP. Ultrasound Obstet Gynecol. 2003 May; 21(5):516-8.
Prenatal diagnosis of de novo terminal deletion of chromosome 7q. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Lee MS, Wang W. Prenat Diagn. 2003 May; 23(5):375-9.
Prenatal diagnosis of otocephaly with microphthalmia/anophthalmia using ultrasound and magnetic resonance imaging. Chen CP, Wang KG, Huang JK, Chang TY, Lin YH, Chin DT, Tzen CY, Wang W. Ultrasound Obstet Gynecol. 2003 Aug;22(2):214-5.
Prenatal diagnosis of choledochal cyst using ultrasound and magnetic resonance imaging. Chen CP, Cheng SJ, Chang TY, Yeh LF, Lin YH, Wang W. Ultrasound Obstet Gynecol. 2004 Jan;23(1):93-4.
Prenatal diagnosis of mosaic distal 5p deletion and review of the literature. Chen CP, Lee CC, Chang TY, Town DD, Wang W. Prenat Diagn. 2004 Jan;24(1):50-7. Review.
Clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 4. Chen CP, Chern SR, Lee CC, Chang TY, Wang W, Tzen CY. Prenat Diagn. 2004 Jan; 24(1):38-44. Review.
Prenatal diagnosis of the distal 11q deletion and review of the literature. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Chen LF, Wang W. Prenat Diagn. 2004 Feb; 24(2):130-6. Review.
Partial trisomy 10 (10q11.2-->pter) and partial trisomy 18 (18p11.2-->pter) associated with abnormal sonographic findings and a maternal serum screen-positive result. Chen CP, Chang TY, Town DD, Chen LF, Pan CW, Wang W, Tzen CY. Ultrasound Obstet Gy- necol. 2004 Feb;23(2):202-4. Review.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Prenatal identification of fetal overgrowth, abdominal wall defect, and neural tube defect in pregnancies achieved by assisted reproductive technology. Chen CP, Lin SP, Hwu YM, Chang TY, Wang W. Prenat Diagn. 2004 May;24(5):396-8.
Prenatal sonographic diagnosis of acrania associated with amniotic bands. Chen CP, Chang TY, Lin YH, Wang W. J Clin Ultrasound. 2004 Jun;32(5):256-60.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Molecular genetic analysis of the TSC genes in two families with prenatally diagnosed rhabdomyomas. Chen CP, Su YN, Hung CC, Lee CN, Hsieh FJ, Chang TY, Chen MR, Wang W. Prenat Diagn. 2005 Feb;25(2):176-8.
Recurrent fetal pyelectasis in a family with fetuses associated with partial trisomy 10q (10q24.1—>qter). Chen CP, Chang TY, Tzen CY, Wang W, Lee CC. Prenat Diagn. 2005 Mar;25(3):263-4.
Prenatal magnetic resonance imaging of Galloway-Mowat syndrome. Chen CP, Chang TY, Lin SP, Huang JK, Tsai JD, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):525-7.
Contribution of ultrafast magnetic resonance imaging in prenatal diagnosis of sonograph- ically undetected cerebral tuberous sclerosis associated with cardiac rhabdomyomas. Chen CP, Liu YP, Huang JK, Chang TY, Chen MR, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):523-4.
Prenatal diagnosis, sonographic findings and molecular genetic analysis of a 46,XX/ 46,XY true hermaphrodite chimera. Chen CP, Chern SR, Sheu JC, Lin SP, Hsu CY, Chang TY, Lee CC, Wang W, Chen HE. Prenat Diagn. 2005 Jun;25(6):502-6.
Prenatal diagnosis of an acardiac amorphous twin and the anomalous co-twin in a monoamniotic twin pregnancy. Chen CP, Shih JC, Chang TY, Chern SR, Lin CY, Wang W, Tzen CY. Prenat Diagn. 2005 Jul;25(7):618-20.
Prenatal magnetic resonance imaging demonstration of the systemic feeding artery of a pulmonary sequestration associated with in utero regression. Chen CP, Liu YP, Lin SP, Sheu JC, Hsu CY, Chang TY, Wang W. Prenat Diagn. 2005 Aug;25(8):721-3.
Prenatal diagnosis of partial trisomy 10q (10q25.3-->qter) and partial monosomy 18q (18q23—>qter). Chen CP, Chern SR, Chang TY, Lee CC, Chen WL, Wang W. Prenat Di- agn. 2005 Nov;25(11):1069-71.
Prenatal diagnosis of the supernumerary der(22)t(11;22) syndrome associated with ab- normal sonographic findings. Chen CP, Wang TH, Chang TY, Lee CC, Chen WL, Chen
LF, Wang W. Genet Couns. 2006;17(4):469-72.
Prenatal two- and three-dimensional ultrasound diagnosis of limb reduction defects associated with homozygous alpha-thalassemia. Chen CP, Chang TY, Su YN, Hsu CY, Wang W. Fetal Diagn Ther. 2006;21(4):374-9. Review.
Recurrent Galloway Mowat syndrome associated with abnormal prenatal sonographic findings. Chen CP, Lin SP, Chang TY, Tsai JD, Huang JK, Wang W. Genet Couns. 2006;17(1):87-9.
Prenatal diagnosis of pure distal 18q deletion. Chen CP, Chern SR, Hung FY, Hsu CY, Chang TY, Lee CC, Town DD, Chen WL, Chen LF, Tzen CY, Wang W, Ma R. Prenat Diagn. 2006 Feb;26(2):184-5.
Prenatal diagnosis of a micropenis in a male fetus with partial trisomy 12q (12q24.32-- >qter) and partial monosomy 21q (21q22.2—>ter-->qter). Chen CP, Lin CC, Chang TY, Li YC, Hsieh LJ, Lee CC, Chen LF, Wang W. Prenat Diagn. 2006 Aug;26(8):757-9.
Second-trimester diagnosis of limb-body wall complex with literature review of patho-
genesis. Chen CP, Lin CJ, Chang TY, Hsu CY, Tzen CY, Wang W. Genet Couns. 2007;18(1):105-12.
Preliminary descriptive statistics of the Taiwanese Registry of Epilepsy and Pregnancy for
the first 2 years. Chang TY, Lai CW, Yu HY, Hsu JJ, Shih YH, Chen CP; Taiwanese Reg-
istry of Epilepsy and Pregnancy. Taiwan J Obstet Gynecol. 2007 Mar;46(1):47-9.
Prenatal diagnosis of the hypoplastic right heart syndrome with sex chromosome penta-
somy (49,XXXXY). Chen CP, Lin CJ, Chang TY, Chern SR, Tzen CY, Chen WL, Wang W. Prenat Diagn. 2007 Mar;27(3):285-6.
Prenatal diagnosis of low-level mosaic tetrasomy 9p by amniocentesis. Chen CP, Chang
TY, Chern SR, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2007 Apr;27(4):383-
5.
Early second-trimester diagnosis of fetal otocephaly. Chen CP, Chang TY, Huang JK,
Wang W. Ultrasound Obstet Gynecol. 2007 Apr;29(4):470-1.
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP, Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal magnetic resonance imaging evaluation of a digynic triploid fetus. Chen CP, Chang TY, Liu YP, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):284-5
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP,
Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal sonographic findings of Klippel-Trénaunay-Weber syndrome. Chen CP, Lin SP,
Chang TY, Lee HC, Hung HY, Lin HY, Huang JP, Wang W. J Clin Ultrasound. 2007 Sep;
35(7):409-12.
Prenatal diagnosis of Fryns syndrome associated with a microdeletion at 8p23.1. Chen CP, Wang TH, Chen YJ, Chang TY, Liu YP, Tzen CY, Chern SR, Wang W. Prenat Diagn.
2007 Oct;27(10):967-9.
Abnormal prenatal hematological findings in congenital leukemia of Down syndrome with hepatosplenomegaly. Chen CP, Lin SP, Chang TY, Ho HT. Prenat Diagn. 2007 Dec; 27(13):1266-7.
Concomitant omphalocele and anencephaly associated with trisomy 18 and arthrogryposis diagnosed in early pregnancy. Chen CP, Chang TY, Lin HH, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):93-4.
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. Chen CP, Chang TY, Hung JH, Chen CY, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):91-2.
Prenatal evaluation with magnetic resonance imaging of a giant blind ectopic ureter asso-ciated with a duplex kidney. Chen CP, Liu YP, Huang JP, Chang TY, Tsai FJ, Tsai JD,Sheu JC, Wang W. Ultrasound Obstet Gynecol. 2008 Mar;31(3):360-2.
Prenatal diagnosis of concomitant Wolf-Hirschhorn syndrome and split hand-foot mal- formation associated with partial monosomy 4p (4p16.1-->pter) and partial trisomy 10q (10q25.1—>qter). Chen CP, Chen YJ, Chern SR, Tsai FJ, Chang TY, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2008 May;28(5):450-3.
Prenatal 3-dimensional sonographic and MRI findings in omphalocele-exstrophy- imperforate anus-spinal defects complex. Chen CP, Chang TY, Liu YP, Tsai FJ, Chien SC,
Tsao CM, Yang HB, Wang W. J Clin Ultrasound. 2008 Jun;36(5):308-11.
Prenatal diagnosis of 46,XX,DER(13;21)(Q10;Q10),+21 and transient abnormal myelopoiesis in a fetus with hepatosplenomegaly and spontaneous resolution of fetal ascites. Chen CP, Tsai FJ, Chern SR, Chang TY, Hsu CY, Lin HH, Wang W. Taiwan J Obstet Gynecol. 2009 Mar;48(1):84-7.
Prenatal magnetic resonance imaging, ultrasound imaging findings and genetic analysis of concomitant rhabdomyomas and cerebral tuberous sclerosis. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Sep;48(3):327-31.
22q11.2 microdeletion in a fetus with double-outlet right ventricle, pulmonary stenosis and a ventricular septal defect: prenatal diagnosis by array comparative genomic hybridization. Chen CP, Su YN, Chang TY, Chern SR, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):437-40.
Prenatal diagnosis of monosomy 17p (17p13.3—>pter) associated with polyhydramnios, intrauterine growth restriction, ventriculomegaly, and Miller-Dieker lissencephaly syndrome in a fetus. Lin CY, Chen CP, Liau CL, Su PH, Tsao TF, Chang TY, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):408-11.
Prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the TSC2 gene. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Chen MR, Hwang JK, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep;49(3):387-9.
Prenatal diagnosis of persistent cloaca with hydrometrocolpos and ascites by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy. Chen CP, Liu YP, Chang TY, Tsai FJ, Chen CY, Wu PC, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep; 49(3):385-6.
The changing face of early-onset neonatal sepsis after the implementation of a maternal group B Streptococcus screening and intrapartum prophylaxis policy--a study in one medical center. Lin CY, Hsu CH, Huang FY, Chang JH, Hung HY, Kao HA, Peng CC, Jim WT, Chi H, Chiu NC, Chang TY, Chen CY, Chen CP. Pediatr Neonatol. 2011 Apr; 52(2):78-84.
Short rib-polydactyly syndrome type II (Majewski): prenatal diagnosis, perinatal imaging findings and molecular analysis of the NEK1 gene. Chen CP, Chang TY, Chen CY, Wang TY, Tsai FJ, Wu PC, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2012 Mar;51(1):100- 5.
Persistent cloaca presenting with a perineal cyst: Prenatal ultrasound and magnetic resonance imaging findings. Chen CP, Chang TY, Hsu CY, Liu YP, Tsai FJ, Wu PC, Wang W. J Chin Med Assoc. 2012 Apr;75(4):190-3.
Osteogenesis imperfecta type II: prenatal diagnosis and association with increased nuchal translucency and hypoechogenicity of the cranium. Chen CP, Su YN, Chang TY, Huang MC, Pan CH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):315- 8.
Identification of a deletion mutation in the short flanking repeat region of exon 44 of the COL1A1 gene in a fetus with osteogenesis imperfecta type II. Chen CP, Su YN, Chang TY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):308-11.
Osteogenesis imperfecta type I: second-trimester diagnosis and incidental identification of a dominant COL1A1 deletion mutation in the paucisymptomatic father. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun; 51(2):276-9.
Prenatal diagnosis and molecular genetic analysis of short rib-polydactyly syndrome type III (Verma-Naumoff) in a second-trimester fetus with a homozygous splice site mutation in intron 4 in the NEK1 gene. Chen CP, Chern SR, Chang TY, Su YN, Chen YY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):266-70.
Prenatal diagnosis of ring chromosome 2 with lissencephaly and 2p25.3 and 2q37.3 microdeletions detected using array comparative genomic hybridization. Chen CP, Lin CJ, Chang TY, Chern SR, Wu PS, Chen YT, Su JW, Lee CC, Chen LF, Wang W. Gene. 2013 Apr 25;519(1):164-8.
Rapid detection of de novo P253R mutation in FGFR2 using uncultured amniocytes in a pregnancy affected by polyhydramnios, Blake's pouch cyst, and Apert syndrome. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Jun;52(2):273-7.
Rapid detection of K650E mutation in FGFR3 using uncultured amniocytes in a pregnan- cy affected with fetal cloverleaf skull, occipital pseudoencephalocele, ventriculomegaly, straight short femurs, and thanatophoric dysplasia type II. Chen CP, Chang TY, Lin MH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):420-5.
Detection of maternal transmission of a splicing mutation in the TSC2 gene following prenatal diagnosis of fetal cardiac rhabdomyomas mimicking congenital cystic adenoma- toid malformation of the lung and cerebral tubers and awareness of a family history of maternal epilepsy. Chen CP, Chang TY, Guo WY, Su YN, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):415-9.
Detection of a de novo Y278C mutation in FGFR3 in a pregnancy with severe fetal hypochondroplasia: prenatal diagnosis and literature review. Chen CP, Su YN, Lin TH, Chang TY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):580-5.
VACTERL association with hydrocephalus in a fetus conceived by in vitro fertilization and embryo transfer. Chen CP, Chang TY, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):575-9.
Chromosome 17p13.3 deletion syndrome: aCGH characterization, prenatal findings and diagnosis, and literature review. Chen CP, Chang TY, Guo WY, Wu PC, Wang LK, Chern SR, Wu PS, Su JW, Chen YT, Chen LF, Wang W. Gene. 2013 Dec 10;532(1):152-9.
Prenatal diagnosis of hypomethylation at KvDMR1 and Beckwith-Wiedemann syndrome in a pregnancy conceived by intracytoplasmic sperm injection and in vitro fertilization and embryo transfer. Chen CP, Su YN, Chen SU, Chang TY, Wu PC, Chern SR, Wu PS, Kuo YL, Wang W. Taiwan J Obstet Gynecol. 2014 Mar;53(1):90-4.
Prenatal diagnosis and molecular cytogenetic characterization of chromosome 22q11.2 deletion syndrome associated with congenital heart defects. Kuo YL, Chen CP, Wang LK, Ko TM, Chang TY, Chern SR, Wu PS, Chen YT, Chang SY. Taiwan J Obstet Gynecol. 2014 Jun;53(2):248-51.
Detection of de novo secondary trisomy 13 due to isochromosome (13q;13q) of paternal origin in a pregnancy with fetal cystic hygroma. Chen CP, Ko TM, Huang MC, Chern SR, Lin TW, Chang TY, Kuo YL, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2015 Feb; 54(1):78-80.
Prenatal diagnosis of chromosome 8p23.1 microdeletion by array comparative genomic hybridization using uncultured amniocytes in a pregnancy associated with fetal partial corpus callosum agenesis and schizencephaly. Chen CP, Peng CR, Chang TY, Guo WY, Chen YN, Wu PS, Town DD, Wang W. Taiwan J Obstet Gynecol. 2015 Dec;54(6):797-8.
Prenatal diagnosis of 22q11.2 deletion syndrome associated with right aortic arch, left ductus arteriosus, cardiomegaly, and pericardial effusion. Chen YN, Chen CP, Ko TM, Wang LK, Wu PC, Chang TY, Wu PS, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2016 Feb;55(1):117-20.
22q13 deletion syndrome in a fetus associated with microtia, hemivertebrae, and congenital heart defects on prenatal ultrasound. Chen CP, Chang TY, Wang LK, Chern SR, Wu PS, Chen YN, Chen SW, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2016 Jun;55(3):455-6.
Prenatal imaging findings of a rapidly involuting congenital hemangioma (RICH) over right flank in a fetus with a favorable outcome. Chen CP, Chen CY, Chang TY, Yang HY, Chen YN, Chen SW, Wang W. Taiwan J Obstet Gynecol. 2016 Oct;55(5):745-747.
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. Chen CP, Wang LK, Wu PC, Chang TY, Chern SR, Wu PS, Chen YN, Chen SW, Lee CC, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2017 Feb;56(1):102-105.
Prenatal diagnosis of persistent left superior vena cava is associated with coarctation of the aorta e A case report. Wen TM, Huang YL, Wu PC, Li YY, Chen MR, Chang TY. Journal of Medical Ultrasound , Volume 25, Issue 4, December 2017, Pages 244-247.
Antiepileptic drug use among women from the Taiwanese Registry of Epilepsy and Preg- nancy: Obstetric complications and fetal malformation outcomes. Yeh CC, Lussier EC, Sun YT, Lan TY, Yu HY, Chang TY. PLoS One. 2017 Dec 18;12(12):e0189497..
Ultrasound screening for developmental dysplasia of the hip after 4 weeks increases exam accuracy and decreases follow-up visits. Lussier EC, Sun YT, Chen HW, Chang TY, Chang CH. Pediatr Neonatol. 2018 Jul 26. pii: S1875-9572(17)30775-1.
Prenatal diagnosis of coarctation of the aorta with ventricular septal defect: A case report. Huang YL, Hsu KH, Enkhzaya Chuluunbaatar, Wen TM, Li YY, Chen MR, Chang CI, Chang TY. Taiwanese Journal of Obstetrics and Gynecology Volume 57, Issue 6, December 2018, Pages 885-889.
Olisova K, Sung CY, Li YY, Hsia CC, Chang TY. One size fits all? A call to establish Taiwanese fetal growth standards. Taiwan J Obstet Gynecol. 2020;59(3):468.
Lussier, E. , Lei, W. , Sun, Y. , Chen, H. , Chang, T. and Chang, C. (2020) Newborn Hip Screenings at 4 to 8 Weeks Are Optimal in Predicting Referral and Treatment Outcomes: A Retrospective Review. Open Journal of Pediatrics, 10, 332-346.
Lussier EC, Yeh SJ, Chih WL, Lin SM, Chou YC, et al. (2020) Reference ranges and Z-scores for fetal cardiac measurements from two-dimensional echocardiography in Asian population. PLOS ONE 15(6): e0233179.
Ko, H., Chang, TY., Lussier, E.C. et al. Multidisciplinary team approach to the prenatal management of orofacial clefts: a single center cohort study in Taiwan. Sci Rep 10, 13916 (2020).
Huang YS, Lussier EC, Olisova K, Chang YC, Ko H, Chang TY. Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair - Eleven years' experiences. Taiwan J Obstet Gynecol. 2021;60(2):281-289.
Harris RC, Fries MH, Boyle A, et al. Multidisciplinary management of pregnancy in complex congenital heart disease: a model for coordination of care. Congenit Heart Dis. 2014;9(6):E204-E211.
Chou YC, Lussier EC, Olisova K, Chang TY. Age-specific effect of fresh versus frozen embryo transfer on fetal anomalies or intrauterine growth restriction rate. Taiwan J Obstet Gynecol. 2021;60(5):831-835. doi:10.1016/j.tjog.2021.07.009
Olisova K, Sung CY, Lussier EC, Chang TY. Revisions to mid-pregnancy cervical length reference range for preterm birth screening among singleton pregnancies in Taiwan - 10 years' experiences. Taiwan J Obstet Gynecol. 2021;60(5):836-839.
The fellowship program for 2022 will start from July, 2022. The admission to the fellowship program and beneficiaries of the scholarship will be announced on May 9, 2022, by email and at this web page.
For application, please email your curriculum vitae, two recommendation letters along with the application form to Aimei Tsui, PhD (aimei.tsui@fetalmedicine.tw) by April 30, 2022.
The fellowship program for 2022 will start from July, 2022. The admission to the fellowship program and beneficiaries of the scholarship will be announced on May 9, 2022, by email and at this web page.
興味のある方はぜひお問い合わせください！
