唇顎裂胎兒診斷及治療
國際唇顎裂研修醫師訓練計畫
About the Fellowship
In 2017, a joint clinic in facial clefts was established by Dr. Philip Kuo-Ting Chen and Dr. Tung-Yao Chang at Taiji Clinic. By integrating the pairs’ expertise in prenatal ultrasound and postnatal facial cleft surgeries, the clinic is able to provide early detection and subsequent counseling during the pregnancy, helping families process and make informed decisions.
After four years of collaboration between the prenatal ultrasound team at Taiji Clinic and the craniofacial team at Taipei Medical University Hospital, the joint clinic, with the help of the Taiwan Institute of Fetal Medicine, established this international fellowship for facial cleft treatment.
The fellowship will train surgeons in the prenatal diagnosis and surgical repair of facial clefts. Surgeons will also learn to communicate better with fetal medicine specialists, provide prenatal counseling to parents, and develop long term relationships with parents post pregnancy.
The fellowship will be launched in July 2022. Applications are accepted until April 30, 2022, with admissions announced on May 9, 2022. Scholarships will be provided for those from the Czech Republic, Japan, Lithuania, Poland, Slovakia, and the United States, as our token of appreciation for these countries’ vaccine donations during the COVID-19 pandemic.
About the Taiwan-Thank-You Scholarship
December 16, 2021
To whom it may concern,
To repay the vaccine donation from Czech, Japan, Lithuania, Poland, Slovakia, and the USA (in alphabetic order) during the pandemic, the Taiwan Institute of Fetal Medicine would like to offer a scholarship to doctors from the above countries to have a 6 month fellowship in Taiwan to learn from prenatal diagnosis to postnatal surgical repair of facial clefts.
The Taiwan Institute of Fetal Medicine, founded in 2019, is a registered nonprofit organization (1080280906) in Taiwan, aiming at promoting fetal medicine. The vaccine donation from the above countries contributed a lot to the health of Taiwan people. We decided to repay the above countries with a fellowship program for facial clefts.
The Taiji Clinic, founded in 2008, is a leading clinic in fetal ultrasound in Taiwan. The Facial Cleft Center, founded in 2017, in the Taipei Medical University Hospital is the third and the newest center for facial cleft treatment in Taiwan, and it serves about 40-50% of the new cases in Taiwan. The two teams have been collaborating since 2017 by organizing a special joint clinic of facial clefts, in which at the same time when the fetal medicine specialist scans the pregnant woman, the plastic surgeon also attends the scan, counsels the parents based on the detailed ultrasound findings, and gives an individualized postnatal surgical plan up to 18 years of age to the parents. The experiences of the joint clinic has been published in the medical journal(#). In short, the parents elected to attend the joint clinic have a much higher chance (85%) to continue pregnancy.
Dr. Philip Kuo-Ting Chen and I will be in charge of the fellowship program. Dr. Chen has rich experiences in teaching international fellows to perform surgical repairs of facial clefts, and my staff and I will teach the fellows ultrasound skills to diagnose facial clefts prenatally. Combining prenatal ultrasound and postnatal surgical repair of facial clefts makes this fellowship program unique and comprehensive. After finishing the 6 month fellowship, the fellows can organize a similar team in their home country and we are happy to provide further support and experiences remotely.
We appreciate the vaccine donation from the above countries very much, and we would like to strengthen our friendship with our fellowship program and scholarship. Please refer to the attached application form and our official webpage for more information.
Sincerely yours,
Tung-yao Chang, MD, M. Med. Sci.
Founder, Taiji Clinic
Founder, Taiwan Institute of Fetal Medicine (https://www.tifm.tw)
Multidisciplinary team approach to the prenatal management of orofacial clefts: a single center cohort study in Taiwan. Hsuan Ko, Tung-Yao Chang, Eric C Lussier, Ksenia Olisova, Chan-Yu Sung, Philip Kuo-Ting Chen, Wen-Chu Li, Tze-Yi Yang, Ru-Xuan Wang. Sci Rep. 2020 Aug 18;10(1):13916
Cleft Lip and Palate Training Course for International Doctors
In January 2018, research doctors from different countries attended a course at Taipei Medical University Hospital to learn about cleft lip and palate surgery and related treatments from Dr. Philip Kuo-Ting Chen.
Photo of doctors (starting from the left): Dr. Dorte Ohrmann (Germany), Dr. Philip Kuo-Ting Chen (Taiwan), Dr. April LS Wong (Malaysia), Dr. Paa Ekow Hoyte-Williams (Ghana)
Doing surgical demonstration to Dr Autelitano from Milan, Italy, in December, 2019.
Photo (second from left): Dr. Autelitano (Milan, Italy)
2023 International Cleft Lip and Palate Trainee Program Dr. Kouki Morita Completion Video
Team for Prenatal Diagnostics and Postpartum Treatment of Cleft Lip and Palate
Live session at the fetal facial clefts joint clinic in the Taiji Clinic, Taipei, Taiwan.
Shown in the photo: fetal medicine specialist, craniofacial surgeon, obstetrician, radiological technologist, pediatric nurse, case manager.
Group photo from the craniofacial center at the Taipei Medical University Hospital.
Staff from the craniofacial center at the Taipei Medical University Hospital and the Fetal Craniofacial Abnormalities Team from Taiji Clinic posed together for a photo at the 12th Annual Taiji Clinic Fetal Medicine Workshop in 2020.
Prenatal diganosis team of the facial clefts
Tze-Yi Yang, M.D
Taiji Clinic
Taiji Clinic
Wen-Ju Li, M.D
Puli Christian Hospital
Puli Christian Hospital
Ru-Xuan Wang, RN
Taiji Clinic
Taiji Clinic
Jia-Heng Li, RT
Taiji Clinic
Taiji Clinic
Ching-Chi Hsia, RT
Taiji Clinic
Taiji Clinic
Fetal cleft lip and palate workshops
Cleft lip and palate support workshop for parents
After prenatal diagnosis of facial clefts, the parents are invited to attend a support workshop to learn how to feed the baby with 3D phantoms of facial clefts.
Dr. Philip Kuo-Ting Chen, the pediatric nurse, the case manager, and experienced volunteer workers will guide the parents to be confident in feeding the baby.
Certification course for fetal cleft lip and palate prenatal-to-postpartum care
A short video describing the support workshop for facial clefts.
In addition to the parents, the workshop is also open to medical professionals, like the nursing staff working in newborn centers, so that they are well trained before the babies of facial clefts are born.
2020.10.31 （Activity record）
2021.03.13（Activity record）
2021.10.17（Activity record）
2021.12.18（Activity record）
Books from the Joint Clinic of Facial Clefts
Little Bunny Grows Up - A Handbook for Treating Cleft Lip and Palate
Published on: September 2020
Supervising Staff: Philip Kuo-Ting Chen, Tung-Yao Chang, Wenju Li
Authors: Tze-Yi Yang, Yen-Ni Chen, Jia-Heng Li, Wan-Ting Su, Ru-Xuan Wang
This reference manual is the first in Taiwan to introduce the treatment of cleft lip and palate through the use of pictures and easy-to-read text, and it will help the parents more easily understand the abnormality as well as the care and treatment schedule after the child’s birth.
Guidebook of Facial Clefts- Postnatal Treatments Made Easy.
Date of publication: January, 2022, in press.
Supervising Staff: Philip Kuo-Ting Chen, Tung-Yao Chang
Production Staff:
Prenatal Team of Facial Clefts at the Taiji Clinic
Craniofacial Center at the Taipei Medical University Hospital
This handbook aims at providing information regarding postnatal treatments of facial clefts to families of facial clefts. The authors are the members of the craniofacial center at the Taipei Medical University Hospital.
Related News
Dr. Ching-Yi Lin Promotes International Medical Collaboration with Vaccine Donation Countries.
From left: Dr. Tung-Yao Chang, Dr. Philip Kuo-Ting Chen, Mr. Ting-Yu Wang, Legislator, Dr. Ching-Yi Lin, Ambassador at Large
Principal Investigator
陳國鼎
Philip Kuo-Ting Chen M.D.
Plastic Surgery
E-mail address： philip.ktchen@gmail.com
Language：Chinese, English
Medical fields of expertise:
Craniofacial reconstruction
Cleft lip and palate
Orthognathic surgery
Plastic surgery (children and adults)
Autologous fat grafting
Education：
1974 - 1981 National Taiwan University, Department of Medicine Taipei, Taiwan, R.O.C. (M.D.)
Postgraduate Training and Past Positions：
July 1980 – June 1981 Internship, National Taiwan University Hospital
July 1981 – June 1984 Residency in General Surgery, Veterans General Hospital, Taipei
July 1984 – June 1986 Residency in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1986 – June 1987 Senior Resident in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1987 – June 1990 Attending Staff in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1990 – June 1991 Clinical Fellow in Craniofacial Surgery, Hospital for Sick Children & University of Toronto, Toronto, Canada
July 1991 – April 1996 Attending Staff in Plastic Surgery,Craniofacial Surgery & Pediatric Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Feb 1992 – July 1993 Instructor in Surgery, Chang Gung Memorial Hospital
July 1993 – July 1997 Assistant Professor in Surgery, Chang Gung Memorial Hospital
April 1996 – Aug 2002 Director of Pediatric Plastic Surgery, Chang Gung Children's Hospital, Taoyuan, Taiwan
July 1997 – July 2011 Associate Professor in Surgery, Chang Gung Memorial Hospital
Aug 1997 – July 2003 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Apr 2000 – July 2006 Deputy-chief in surgery, Chang Gung Children’s Hospital, Taoyuan
Nov 1998 – Nov 2006 Council member in the Asian Pacific Craniofacial Association
Jan 2001 – Feb 2007 President, Taiwan Cleft Palate-Craniofacial Association
Nov 2003 – July 2007 Vice Chairman, Department of Plastic & Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei
Dec 2004 – Nov 2008 Council member, Plastic Surgery Association, ROC
Nov 2006 – Oct 2008 President, Asian Pacific Craniofacial Association
Dec 2006 – Dec 2010 Council member, Taiwan Society of Aesthetic & Plastic Surgery
May 2006 – May 2014 National secretary for Chinese Taipei in International Society of Aesthetic Plastic Surgery
July 2006 – June 2014 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei & Taoyuan
Aug 2011 – June 2017 Board member, Asian Pacific Region, AOCMF
July 2011 – Sep 2017 Professor in Surgery, Chang Gung Memorial Hospital
Jan 2012 – Sep 2017 Director, Craniofacial center, Chang Gung Memorial Hospital, Taoyuan
Jun 2007 – May 2019 Medical Advisory Board, The Smile Train
Present Position：
Apr 2000 – Present Board member, Noordhoff Craniofacial Foundation
Feb 2007 – present Council member, Taiwan Cleft Palate –Craniofacial Association
Oct 2017 – Present Director, Craniofacial Center, Taipei Medical University Hospital
Professional Affiliation：
Surgical Association, Taiwan.
Plastic Surgery Association, Taiwan.
Taiwan Cleft Palate-Craniofacial Association
American Cleft Palate-Craniofacial Anomaly Association
Taiwan Society of Aesthetic & Plastic Surgery
Asian Pacific Craniofacial Surgical Association
Clinical Interests：
Craniofacial surgery
Cleft lip/palate
Pediatric plastic surgery
Facial cosmetic surgery
Researches：
1.NSC88-2314-B-182A-016, 1998-1999 – An animal Model in Experimental Studies of Maxillary Growth after Palatoplasty under Microscopic Magnification.
2.CMRP774 – The Effect of the Residual Alveolar Cleft on the Nasal Structure and Physiology in Cleft Patients.
3.NSC89-2314-B-182-098 – Assessment of Lip Function after Lip Repair (Co-investigator)
4.NSC90-2320-B-182A-00, 2001-2003 – Genetic epidemiologic study on oral clefts by association and transmission disequilibrium test in Taiwan. (Co-investigator)
5.NSC90-2212-E-008-025, 2001-2002 – A computer-assisted simulation, planning and navigation system for craniofacial reconstructive and plastic surgery. (Co-investigator)
6.NSC90-2212-E-182A-001, 2001-2003 – The design and fabrication of defect implants, planning and simulation of craniofacial reconstruction.
7.NSC91-2314-B-182A-119, 2002-2003 – Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial
8.NSC92-2314-B-182A-173, 2003-2004 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (1)
9.NSC93-2314-B-182A-020,2004-2005 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (2)
10.NSC95-2314-B-182A-043, 2006-2007 – Sensory recovery after facial bone injury
11.NIH grant R01 DE014581-01A1, 2004-2008 – International genetic epidemiology of oral clefts. (Co-investigator)
12.SMRPG34002, 2004-2006 – Clinical manifestation and biomedical study on neurofibromatosis. (Co-investigator)
13.SQCP01 – A controlled randomized study for the speech and growth outcome between two different timing and techniques of cleft palate repair.
14.CMRPG390731, 2010-2013 – Botulinum toxin to improve results in cleft lip repair
15.CMRPG390721, 2010-2013 -- Long term comparison of two nasoalveolar molding techniques in complete unilateral cleft lip patients
16.CMRPG590011, 2010-2013 -- Morphological change of chest wall after harvesting the costal cartilage. (Co-investigator)
17.CMRPG5C0111, 2013-2014 -- Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial. (Co-investigator)
18. CMRPG5C0101, 2013-2014 -- The establishment of an integrated database on oral clefts. (Co-investigator)
19.CMRPG5C0121, 2013-2014 -- Stability of One-piece versus Two-piece Le Fort I Osteotomy: A Prospective Study. (Co-investigator)
20. CRRPG5C0131, 2013-2014 -- Comparative Outcomes of Alveolar Bone Grafting versus Gingivoperiosteoplasty at the Time of Le Fort I Osteotomy: A Prospective Randomized Trial. (Co-investigator)
21.CRRPG5C0141, 2013-2014 -- Inferior Alveolar Nerve Injury after Bilateral Sagittal Split Osteotomy in Oral Clefts. (Co-investigator)
22.CRRPG5C0071, 2014-2016 -- The impacts of Orthognathic Surgery on Speech and Velopharyngeal function of patients with Cleft Lip and Palate.
23. CRRPG5C0061, 2014-2016 -- Using clinical audiology to seek for related hearing changes following Orthognathic surgery in cleft patients. (Co-investigator)
24. CRRPG5C0051, 2014-2016 -- Airway Changes after Cleft Orthognathic Surgery Evaluated by Three Dimensional Computed Tomography and Overnight Polysomnographic Study. (Co-investigator)
25. CRRPG5C0041, 2014-2016 -- The changes of periodontal tissues following orthognathic surgery in patients with unilateral cleft lip and palate. (Co-investigator)
26. CRRPG5C0031, 2014-2016 -- Post Operative Stability of Surgery First or Orthodontic First in Unilateral Cleft lip and Palate. (Co-investigator)
27. XMRPG1E0091, 2015-2016 -- BOTOX Treatment of Masseter Muscle Hypertrophy.
28. CMRPG5E0061, 2015-2016 -- Clinical evaluation of silicone gel in the treatment of cleft lip scars.(Co-investigator)
29. CMRPG5F0021, 2015-2016 -- The Use of New Designed Nasal Splint in the Primary Management of Unilateral Cleft Nasal Deformity.(Co-investigator)
30. CMRPG5F0061, 2016 – Craniofacial Risk Factors of Obstrctive Sleep Apnea Following Pharyngeal Flap for Secondary Velopharyngeal Insufficiency. (Co-investigator)
31. CMRPG3F0731, 2016-2017 -- The Effect of Botulinum Toxin to unilateral cleft lip scar and nostril width.
32. NMRPG5F0051, 2016-2017 – Long Term Comparison Study of Philtral Ridge Morphology with Two Different Techniques of Philtral Reconstruction. (Co-investigator)
33. NMRPG3F0471, 2016-2017 -- Botulinum Toxin for the prevention of widening of unilateral cleft lip nose.
34. 1789-301-008, 2019-2021 -- BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
35. 109-2314-B-038-035-, 110-2314-B-038 -168 -, 2020-2022 -- The evaluation and treatment of nasal obstruction in unilateral cleft lip and palate patients.
Honor & Award：
Best paper award: Philip KT Chen, J Wu, YR Chen, MS Noordhoff: Correction of secondary velopharyngeal insufficiency in cleft palate patients with Furlow palatoplasty. Plast Reconstr Surg 94:933, 1994. Best paper award for the American Society of Maxillofacial Surgery, 1995
Best paper award: Eric JW Liou, Philip KT Chen, CS Huang, YR Chen: Interdental Distraction Osteogenesis and Rapid Tooth Movement: A Novel Approach to Approximate a Wide Alveolar Cleft or Bony Defect: Plast Reconstr Surg 105(4): 1262, 2000. Best paper award for the American Society of Maxillofacial Surgery, 2001
Visiting expertise in the Expertise Course of Hong Kong Plastic Surgery Society. Hong Kong, Jan, 2001.
Visiting expertise for the Great Ormond Street Hospital for Children, Nov, 2003
“Millard’s Visiting Professor Oration” in 4th Annual Congress of the Indian Society of Cleft Lip, Palate and Craniofacial Anomalies, Hyderabad, India, 2005
Visiting professor, Jiaotung University, Xian, China, Apr, 2009
“Godrej visiting professor oration”. In Annual meeting of the Association of Plastic surgeons of India, Chandigarh, India, 2014
Best paper award: CS Chang, CG Wallace, YC Hsiao, CJ Chang, PKT Chen: Botulinum Toxin to Improve Results in Cleft Lip Repair. Plast Reconstr Surg 134(3):511-516, 2014 (Corresponding author). PRS best paper award 2015.
“Best International Collaboration Paper-Gold, 2016” (PRS Global Open 3(3);e313, 2015: A Model Humanitarian Cleft Mission: 312 cleft surgeries in 7 days. GQ Fayyaz, NA Gill, I Ishaq, MA Ganatra, F Mahmood, M Kashif, I Alam, P KT Chen, LJ Lo, DR Laub)
張東曜
Tung-Yao Chang
Founder of Taiji Clinic
E-mail address： tychang@fetalmedicine.tw
Language：Chinese, English
Education：
1995-1992 Department of Medicine, Taipei Medical College, Taiwan
1998-1999 School of Human Development, University of Nottingham, UK (Master of Medical Science in Obstetric Ultrasound)
2003-2008 School of Medical Science, Taipei Medical University, Taiwan (PhD candidate in Medical Information)
Clinical Training:
Residency, department of ob/gyn, Ministry of Health Taipei County Hospital, Taipei County, Taiwan, 1993-1994.
Residency, department of ob/gyn, Taipei Mackay Memorial Hospital, Taipei, Taipei, Taiwan, 1994-1998.
Joint advanced course in obstetric ultrasound of RCOG & RCR, Pregnancy Assessment Centre, Queen’s Medical Centre, Nottingham, UK, 1998-1999.
Clinical observer, Harris Birthright Foetal Medicine Centre, King’s College London, UK, 1999
Fellowship, department of high risk pregnancy, Taipei Mackay Memorial Hospital, Taipei, Taiwan, 1999-2001
Current Position:
Founder and doctor, Taiji Clinic, from 2008
Publication ：
Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Chen CP, Chern SR, Shih JC, Wang W, Yeh LF, Chang TY, Tzen CY. Prenat Diagn. 2001 Feb;21(2):89-95.
Prenatal diagnosis of de novo distal 11q deletion associated with sonographic findings of unilateral duplex renal system, pyelectasis and orofacial clefts. Chen CP, Chern SR, Tzen CY, Lee MS, Pan CW, Chang TY, Wang W. Prenat Diagn. 2001 Apr;21(4):317-20.
Prenatal diagnosis of partial monosomy 18p(18p11.2-->pter) and trisomy 21q(21q22.3-- >qter) with alobar holoprosencephaly and premaxillary agenesis. Chen CP, Chern SR, Wang W, Lee CC, Chen WL, Chen LF, Chang TY, Tzen CY. Prenat Diagn. 2001 May; 21(5):346-50. Review.
Resolution of fetal bilateral chylothorax and ascites after two unilateral thoracocenteses. Chen CP, Chang TY, Wang W. Ultrasound Obstet Gynecol. 2001 Oct;18(4):401-2.
Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome. Chen CP, Sheu JC, Wang W, Lin SP, Chang TY, Tzen CY. Prenat Diagn. 2002 Feb;22(2):166.
Sonographic appearance of the uterus after simple square suturing for rapid control of postpartum hemorrhage and preservation of fertility. Chen CP, Chang TY, Yeh LF, Lin CJ, Wang W. J Clin Ultrasound. 2002 Mar-Apr;30(3):189-91.
Sonographic detection of situs inversus, ventricular septal defect, and short-rib polydacty-ly syndrome type III (Verma-Naumoff) in a second-trimester fetus not known to be at risk. Chen CP, Chang TY, Tzen CY, Lin CJ, Wang W. Ultrasound Obstet Gynecol. 2002 Jun;19(6):629-31.
Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb- body wall complex. Chen CP, Tzen CY, Chang TY, Yeh LF, Wang W. Ultrasound Obstet Gynecol. 2002 Jul;20(1):94-5.
Second trimester molecular diagnosis of a stop codon FGFR3 mutation in a type I thanatophoric dysplasia fetus following abnormal ultrasound findings. Chen CP, Chern SR, Chang TY, Lin CJ, Wang W, Tzen CY. Prenat Diagn. 2002 Aug;22(8):736-7.
Perinatal imaging findings of inherited Sotos syndrome. Chen CP, Lin SP, Chang TY, Chiu NC, Shih SL, Lin CJ, Wang W, Hsu HC. Prenat Diagn. 2002 Oct;22(10):887-92.
Prenatal diagnosis of partial trisomy 3p and partial monosomy 11q in a fetus with a Dandy-Walker variant and trigonocephaly. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Town DD, Chen LF, Lee MS. Prenat Diagn. 2002 Dec;22(12):1112-3.
Prenatal diagnosis of the Dandy-Walker malformation and ventriculomegaly associated with partial trisomy 9p and distal 12p deletion. Chen CP, Chang TY, Shih JC, Lin SP, Lin CJ, Wang W, Lee CC, Town DD, Pan CW, Tzen CY. Prenat Diagn. 2002 Dec;22(12): 1063-6.
Prenatal diagnosis of mosaic ring chromosome 22 associated with cardiovascular abnor- malities and intrauterine growth restriction. Chen CP, Chern SR, Chang TY, Lee CC, Chen LF, Tzen CY, Wang W, Lin CJ, Yang BP, Yang LS. Prenat Diagn. 2003 Jan;23(1): 40-3.
Prenatal diagnosis of de novo mosaic distal 18q deletion associated with congenital anomalies. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Chen LF, Chen WL. Ultrasound Obstet Gynecol. 2003 Feb;21(2):202-4.
Second-trimester sonographic detection of short rib-polydactyly syndrome type II (Majewski) following an abnormal maternal serum biochemical screening result. Chen CP, Chang TY, Tzen CY, Wang W. Prenat Diagn. 2003 Apr;23(4):353-5.
Early second-trimester diagnosis of monozygotic twins discordant for cystic hygroma col- li and Turner syndrome. Chen CP, Chang TY, Chern SR, Town DD, Pan CW, Lee MS, Wang W. Prenat Diagn. 2003 Apr;23(4):352-3.
Second-trimester sonographic demonstration of retrognathia and bilateral pyelectasis in a fetus with a duplication of chromosome 10q24.1—>qter. Chen CP, Chang TY, Tzen CY, Wang W, Lee CC, Chen LF, Lee MS, Lin SP. Ultrasound Obstet Gynecol. 2003 May; 21(5):516-8.
Prenatal diagnosis of de novo terminal deletion of chromosome 7q. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Lee MS, Wang W. Prenat Diagn. 2003 May; 23(5):375-9.
Prenatal diagnosis of otocephaly with microphthalmia/anophthalmia using ultrasound and magnetic resonance imaging. Chen CP, Wang KG, Huang JK, Chang TY, Lin YH, Chin DT, Tzen CY, Wang W. Ultrasound Obstet Gynecol. 2003 Aug;22(2):214-5.
Prenatal diagnosis of choledochal cyst using ultrasound and magnetic resonance imaging. Chen CP, Cheng SJ, Chang TY, Yeh LF, Lin YH, Wang W. Ultrasound Obstet Gynecol. 2004 Jan;23(1):93-4.
Prenatal diagnosis of mosaic distal 5p deletion and review of the literature. Chen CP, Lee CC, Chang TY, Town DD, Wang W. Prenat Diagn. 2004 Jan;24(1):50-7. Review.
Clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 4. Chen CP, Chern SR, Lee CC, Chang TY, Wang W, Tzen CY. Prenat Diagn. 2004 Jan; 24(1):38-44. Review.
Prenatal diagnosis of the distal 11q deletion and review of the literature. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Chen LF, Wang W. Prenat Diagn. 2004 Feb; 24(2):130-6. Review.
Partial trisomy 10 (10q11.2-->pter) and partial trisomy 18 (18p11.2-->pter) associated with abnormal sonographic findings and a maternal serum screen-positive result. Chen CP, Chang TY, Town DD, Chen LF, Pan CW, Wang W, Tzen CY. Ultrasound Obstet Gy- necol. 2004 Feb;23(2):202-4. Review.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Prenatal identification of fetal overgrowth, abdominal wall defect, and neural tube defect in pregnancies achieved by assisted reproductive technology. Chen CP, Lin SP, Hwu YM, Chang TY, Wang W. Prenat Diagn. 2004 May;24(5):396-8.
Prenatal sonographic diagnosis of acrania associated with amniotic bands. Chen CP, Chang TY, Lin YH, Wang W. J Clin Ultrasound. 2004 Jun;32(5):256-60.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Molecular genetic analysis of the TSC genes in two families with prenatally diagnosed rhabdomyomas. Chen CP, Su YN, Hung CC, Lee CN, Hsieh FJ, Chang TY, Chen MR, Wang W. Prenat Diagn. 2005 Feb;25(2):176-8.
Recurrent fetal pyelectasis in a family with fetuses associated with partial trisomy 10q (10q24.1—>qter). Chen CP, Chang TY, Tzen CY, Wang W, Lee CC. Prenat Diagn. 2005 Mar;25(3):263-4.
Prenatal magnetic resonance imaging of Galloway-Mowat syndrome. Chen CP, Chang TY, Lin SP, Huang JK, Tsai JD, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):525-7.
Contribution of ultrafast magnetic resonance imaging in prenatal diagnosis of sonograph- ically undetected cerebral tuberous sclerosis associated with cardiac rhabdomyomas. Chen CP, Liu YP, Huang JK, Chang TY, Chen MR, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):523-4.
Prenatal diagnosis, sonographic findings and molecular genetic analysis of a 46,XX/ 46,XY true hermaphrodite chimera. Chen CP, Chern SR, Sheu JC, Lin SP, Hsu CY, Chang TY, Lee CC, Wang W, Chen HE. Prenat Diagn. 2005 Jun;25(6):502-6.
Prenatal diagnosis of an acardiac amorphous twin and the anomalous co-twin in a monoamniotic twin pregnancy. Chen CP, Shih JC, Chang TY, Chern SR, Lin CY, Wang W, Tzen CY. Prenat Diagn. 2005 Jul;25(7):618-20.
Prenatal magnetic resonance imaging demonstration of the systemic feeding artery of a pulmonary sequestration associated with in utero regression. Chen CP, Liu YP, Lin SP, Sheu JC, Hsu CY, Chang TY, Wang W. Prenat Diagn. 2005 Aug;25(8):721-3.
Prenatal diagnosis of partial trisomy 10q (10q25.3-->qter) and partial monosomy 18q (18q23—>qter). Chen CP, Chern SR, Chang TY, Lee CC, Chen WL, Wang W. Prenat Di- agn. 2005 Nov;25(11):1069-71.
Prenatal diagnosis of the supernumerary der(22)t(11;22) syndrome associated with ab- normal sonographic findings. Chen CP, Wang TH, Chang TY, Lee CC, Chen WL, Chen
LF, Wang W. Genet Couns. 2006;17(4):469-72.
Prenatal two- and three-dimensional ultrasound diagnosis of limb reduction defects associated with homozygous alpha-thalassemia. Chen CP, Chang TY, Su YN, Hsu CY, Wang W. Fetal Diagn Ther. 2006;21(4):374-9. Review.
Recurrent Galloway Mowat syndrome associated with abnormal prenatal sonographic findings. Chen CP, Lin SP, Chang TY, Tsai JD, Huang JK, Wang W. Genet Couns. 2006;17(1):87-9.
Prenatal diagnosis of pure distal 18q deletion. Chen CP, Chern SR, Hung FY, Hsu CY, Chang TY, Lee CC, Town DD, Chen WL, Chen LF, Tzen CY, Wang W, Ma R. Prenat Diagn. 2006 Feb;26(2):184-5.
Prenatal diagnosis of a micropenis in a male fetus with partial trisomy 12q (12q24.32-- >qter) and partial monosomy 21q (21q22.2—>ter-->qter). Chen CP, Lin CC, Chang TY, Li YC, Hsieh LJ, Lee CC, Chen LF, Wang W. Prenat Diagn. 2006 Aug;26(8):757-9.
Second-trimester diagnosis of limb-body wall complex with literature review of patho-
genesis. Chen CP, Lin CJ, Chang TY, Hsu CY, Tzen CY, Wang W. Genet Couns. 2007;18(1):105-12.
Preliminary descriptive statistics of the Taiwanese Registry of Epilepsy and Pregnancy for
the first 2 years. Chang TY, Lai CW, Yu HY, Hsu JJ, Shih YH, Chen CP; Taiwanese Reg-
istry of Epilepsy and Pregnancy. Taiwan J Obstet Gynecol. 2007 Mar;46(1):47-9.
Prenatal diagnosis of the hypoplastic right heart syndrome with sex chromosome penta-
somy (49,XXXXY). Chen CP, Lin CJ, Chang TY, Chern SR, Tzen CY, Chen WL, Wang W. Prenat Diagn. 2007 Mar;27(3):285-6.
Prenatal diagnosis of low-level mosaic tetrasomy 9p by amniocentesis. Chen CP, Chang
TY, Chern SR, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2007 Apr;27(4):383-
5.
Early second-trimester diagnosis of fetal otocephaly. Chen CP, Chang TY, Huang JK,
Wang W. Ultrasound Obstet Gynecol. 2007 Apr;29(4):470-1.
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP, Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal magnetic resonance imaging evaluation of a digynic triploid fetus. Chen CP, Chang TY, Liu YP, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):284-5
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP,
Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal sonographic findings of Klippel-Trénaunay-Weber syndrome. Chen CP, Lin SP,
Chang TY, Lee HC, Hung HY, Lin HY, Huang JP, Wang W. J Clin Ultrasound. 2007 Sep;
35(7):409-12.
Prenatal diagnosis of Fryns syndrome associated with a microdeletion at 8p23.1. Chen CP, Wang TH, Chen YJ, Chang TY, Liu YP, Tzen CY, Chern SR, Wang W. Prenat Diagn.
2007 Oct;27(10):967-9.
Abnormal prenatal hematological findings in congenital leukemia of Down syndrome with hepatosplenomegaly. Chen CP, Lin SP, Chang TY, Ho HT. Prenat Diagn. 2007 Dec; 27(13):1266-7.
Concomitant omphalocele and anencephaly associated with trisomy 18 and arthrogryposis diagnosed in early pregnancy. Chen CP, Chang TY, Lin HH, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):93-4.
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. Chen CP, Chang TY, Hung JH, Chen CY, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):91-2.
Prenatal evaluation with magnetic resonance imaging of a giant blind ectopic ureter asso-ciated with a duplex kidney. Chen CP, Liu YP, Huang JP, Chang TY, Tsai FJ, Tsai JD,Sheu JC, Wang W. Ultrasound Obstet Gynecol. 2008 Mar;31(3):360-2.
Prenatal diagnosis of concomitant Wolf-Hirschhorn syndrome and split hand-foot mal- formation associated with partial monosomy 4p (4p16.1-->pter) and partial trisomy 10q (10q25.1—>qter). Chen CP, Chen YJ, Chern SR, Tsai FJ, Chang TY, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2008 May;28(5):450-3.
Prenatal 3-dimensional sonographic and MRI findings in omphalocele-exstrophy- imperforate anus-spinal defects complex. Chen CP, Chang TY, Liu YP, Tsai FJ, Chien SC,
Tsao CM, Yang HB, Wang W. J Clin Ultrasound. 2008 Jun;36(5):308-11.
Prenatal diagnosis of 46,XX,DER(13;21)(Q10;Q10),+21 and transient abnormal myelopoiesis in a fetus with hepatosplenomegaly and spontaneous resolution of fetal ascites. Chen CP, Tsai FJ, Chern SR, Chang TY, Hsu CY, Lin HH, Wang W. Taiwan J Obstet Gynecol. 2009 Mar;48(1):84-7.
Prenatal magnetic resonance imaging, ultrasound imaging findings and genetic analysis of concomitant rhabdomyomas and cerebral tuberous sclerosis. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Sep;48(3):327-31.
22q11.2 microdeletion in a fetus with double-outlet right ventricle, pulmonary stenosis and a ventricular septal defect: prenatal diagnosis by array comparative genomic hybridization. Chen CP, Su YN, Chang TY, Chern SR, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):437-40.
Prenatal diagnosis of monosomy 17p (17p13.3—>pter) associated with polyhydramnios, intrauterine growth restriction, ventriculomegaly, and Miller-Dieker lissencephaly syndrome in a fetus. Lin CY, Chen CP, Liau CL, Su PH, Tsao TF, Chang TY, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):408-11.
Prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the TSC2 gene. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Chen MR, Hwang JK, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep;49(3):387-9.
Prenatal diagnosis of persistent cloaca with hydrometrocolpos and ascites by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy. Chen CP, Liu YP, Chang TY, Tsai FJ, Chen CY, Wu PC, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep; 49(3):385-6.
The changing face of early-onset neonatal sepsis after the implementation of a maternal group B Streptococcus screening and intrapartum prophylaxis policy--a study in one medical center. Lin CY, Hsu CH, Huang FY, Chang JH, Hung HY, Kao HA, Peng CC, Jim WT, Chi H, Chiu NC, Chang TY, Chen CY, Chen CP. Pediatr Neonatol. 2011 Apr; 52(2):78-84.
Short rib-polydactyly syndrome type II (Majewski): prenatal diagnosis, perinatal imaging findings and molecular analysis of the NEK1 gene. Chen CP, Chang TY, Chen CY, Wang TY, Tsai FJ, Wu PC, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2012 Mar;51(1):100- 5.
Persistent cloaca presenting with a perineal cyst: Prenatal ultrasound and magnetic resonance imaging findings. Chen CP, Chang TY, Hsu CY, Liu YP, Tsai FJ, Wu PC, Wang W. J Chin Med Assoc. 2012 Apr;75(4):190-3.
Osteogenesis imperfecta type II: prenatal diagnosis and association with increased nuchal translucency and hypoechogenicity of the cranium. Chen CP, Su YN, Chang TY, Huang MC, Pan CH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):315- 8.
Identification of a deletion mutation in the short flanking repeat region of exon 44 of the COL1A1 gene in a fetus with osteogenesis imperfecta type II. Chen CP, Su YN, Chang TY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):308-11.
Osteogenesis imperfecta type I: second-trimester diagnosis and incidental identification of a dominant COL1A1 deletion mutation in the paucisymptomatic father. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun; 51(2):276-9.
Prenatal diagnosis and molecular genetic analysis of short rib-polydactyly syndrome type III (Verma-Naumoff) in a second-trimester fetus with a homozygous splice site mutation in intron 4 in the NEK1 gene. Chen CP, Chern SR, Chang TY, Su YN, Chen YY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):266-70.
Prenatal diagnosis of ring chromosome 2 with lissencephaly and 2p25.3 and 2q37.3 microdeletions detected using array comparative genomic hybridization. Chen CP, Lin CJ, Chang TY, Chern SR, Wu PS, Chen YT, Su JW, Lee CC, Chen LF, Wang W. Gene. 2013 Apr 25;519(1):164-8.
Rapid detection of de novo P253R mutation in FGFR2 using uncultured amniocytes in a pregnancy affected by polyhydramnios, Blake's pouch cyst, and Apert syndrome. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Jun;52(2):273-7.
Rapid detection of K650E mutation in FGFR3 using uncultured amniocytes in a pregnan- cy affected with fetal cloverleaf skull, occipital pseudoencephalocele, ventriculomegaly, straight short femurs, and thanatophoric dysplasia type II. Chen CP, Chang TY, Lin MH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):420-5.
Detection of maternal transmission of a splicing mutation in the TSC2 gene following prenatal diagnosis of fetal cardiac rhabdomyomas mimicking congenital cystic adenoma- toid malformation of the lung and cerebral tubers and awareness of a family history of maternal epilepsy. Chen CP, Chang TY, Guo WY, Su YN, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):415-9.
Detection of a de novo Y278C mutation in FGFR3 in a pregnancy with severe fetal hypochondroplasia: prenatal diagnosis and literature review. Chen CP, Su YN, Lin TH, Chang TY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):580-5.
VACTERL association with hydrocephalus in a fetus conceived by in vitro fertilization and embryo transfer. Chen CP, Chang TY, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):575-9.
Chromosome 17p13.3 deletion syndrome: aCGH characterization, prenatal findings and diagnosis, and literature review. Chen CP, Chang TY, Guo WY, Wu PC, Wang LK, Chern SR, Wu PS, Su JW, Chen YT, Chen LF, Wang W. Gene. 2013 Dec 10;532(1):152-9.
Prenatal diagnosis of hypomethylation at KvDMR1 and Beckwith-Wiedemann syndrome in a pregnancy conceived by intracytoplasmic sperm injection and in vitro fertilization and embryo transfer. Chen CP, Su YN, Chen SU, Chang TY, Wu PC, Chern SR, Wu PS, Kuo YL, Wang W. Taiwan J Obstet Gynecol. 2014 Mar;53(1):90-4.
Prenatal diagnosis and molecular cytogenetic characterization of chromosome 22q11.2 deletion syndrome associated with congenital heart defects. Kuo YL, Chen CP, Wang LK, Ko TM, Chang TY, Chern SR, Wu PS, Chen YT, Chang SY. Taiwan J Obstet Gynecol. 2014 Jun;53(2):248-51.
Detection of de novo secondary trisomy 13 due to isochromosome (13q;13q) of paternal origin in a pregnancy with fetal cystic hygroma. Chen CP, Ko TM, Huang MC, Chern SR, Lin TW, Chang TY, Kuo YL, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2015 Feb; 54(1):78-80.
Prenatal diagnosis of chromosome 8p23.1 microdeletion by array comparative genomic hybridization using uncultured amniocytes in a pregnancy associated with fetal partial corpus callosum agenesis and schizencephaly. Chen CP, Peng CR, Chang TY, Guo WY, Chen YN, Wu PS, Town DD, Wang W. Taiwan J Obstet Gynecol. 2015 Dec;54(6):797-8.
Prenatal diagnosis of 22q11.2 deletion syndrome associated with right aortic arch, left ductus arteriosus, cardiomegaly, and pericardial effusion. Chen YN, Chen CP, Ko TM, Wang LK, Wu PC, Chang TY, Wu PS, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2016 Feb;55(1):117-20.
22q13 deletion syndrome in a fetus associated with microtia, hemivertebrae, and congenital heart defects on prenatal ultrasound. Chen CP, Chang TY, Wang LK, Chern SR, Wu PS, Chen YN, Chen SW, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2016 Jun;55(3):455-6.
Prenatal imaging findings of a rapidly involuting congenital hemangioma (RICH) over right flank in a fetus with a favorable outcome. Chen CP, Chen CY, Chang TY, Yang HY, Chen YN, Chen SW, Wang W. Taiwan J Obstet Gynecol. 2016 Oct;55(5):745-747.
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. Chen CP, Wang LK, Wu PC, Chang TY, Chern SR, Wu PS, Chen YN, Chen SW, Lee CC, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2017 Feb;56(1):102-105.
Prenatal diagnosis of persistent left superior vena cava is associated with coarctation of the aorta e A case report. Wen TM, Huang YL, Wu PC, Li YY, Chen MR, Chang TY. Journal of Medical Ultrasound , Volume 25, Issue 4, December 2017, Pages 244-247.
Antiepileptic drug use among women from the Taiwanese Registry of Epilepsy and Preg- nancy: Obstetric complications and fetal malformation outcomes. Yeh CC, Lussier EC, Sun YT, Lan TY, Yu HY, Chang TY. PLoS One. 2017 Dec 18;12(12):e0189497..
Ultrasound screening for developmental dysplasia of the hip after 4 weeks increases exam accuracy and decreases follow-up visits. Lussier EC, Sun YT, Chen HW, Chang TY, Chang CH. Pediatr Neonatol. 2018 Jul 26. pii: S1875-9572(17)30775-1.
Prenatal diagnosis of coarctation of the aorta with ventricular septal defect: A case report. Huang YL, Hsu KH, Enkhzaya Chuluunbaatar, Wen TM, Li YY, Chen MR, Chang CI, Chang TY. Taiwanese Journal of Obstetrics and Gynecology Volume 57, Issue 6, December 2018, Pages 885-889.
Olisova K, Sung CY, Li YY, Hsia CC, Chang TY. One size fits all? A call to establish Taiwanese fetal growth standards. Taiwan J Obstet Gynecol. 2020;59(3):468.
Lussier, E. , Lei, W. , Sun, Y. , Chen, H. , Chang, T. and Chang, C. (2020) Newborn Hip Screenings at 4 to 8 Weeks Are Optimal in Predicting Referral and Treatment Outcomes: A Retrospective Review. Open Journal of Pediatrics, 10, 332-346.
Lussier EC, Yeh SJ, Chih WL, Lin SM, Chou YC, et al. (2020) Reference ranges and Z-scores for fetal cardiac measurements from two-dimensional echocardiography in Asian population. PLOS ONE 15(6): e0233179.
Ko, H., Chang, TY., Lussier, E.C. et al. Multidisciplinary team approach to the prenatal management of orofacial clefts: a single center cohort study in Taiwan. Sci Rep 10, 13916 (2020).
Huang YS, Lussier EC, Olisova K, Chang YC, Ko H, Chang TY. Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair - Eleven years' experiences. Taiwan J Obstet Gynecol. 2021;60(2):281-289.
Harris RC, Fries MH, Boyle A, et al. Multidisciplinary management of pregnancy in complex congenital heart disease: a model for coordination of care. Congenit Heart Dis. 2014;9(6):E204-E211.
Chou YC, Lussier EC, Olisova K, Chang TY. Age-specific effect of fresh versus frozen embryo transfer on fetal anomalies or intrauterine growth restriction rate. Taiwan J Obstet Gynecol. 2021;60(5):831-835. doi:10.1016/j.tjog.2021.07.009
Olisova K, Sung CY, Lussier EC, Chang TY. Revisions to mid-pregnancy cervical length reference range for preterm birth screening among singleton pregnancies in Taiwan - 10 years' experiences. Taiwan J Obstet Gynecol. 2021;60(5):836-839.
The fellowship program for 2022 will start from July, 2022. The admission to the fellowship program and beneficiaries of the scholarship will be announced on May 9, 2022, by email and at this web page.
