唇顎裂胎兒診斷及治療
國際唇顎裂研修醫師訓練計畫
本計畫預計於2022年正式展開
自 2017 年 12 月起,北醫顱顏中心陳國鼎醫師團隊與台灣產前診斷權威台兒診所合作,開立「胎兒唇顎裂聯合門診」。在台兒診所胎檢醫師精確診斷唇顎裂的形式與程度後,可以透過整形外科團隊精確且完整地,向準父母們說明孩子出生後的治療計畫與預後,幫助家長思考及判斷,並有效降低異常胎兒出生後對於家庭的身心衝擊。 雙方合作長達四年的唇顎裂聯合醫療諮詢的模式,不僅榮獲國家品質標章的認證,也堪稱為台灣唇顎裂醫療模式的典範。
本計畫以鼓勵交流學習的方式,邀請有志於從事胎兒顱顏異常診斷及治療的國際醫師至我國進行研修,透過完整的訓練計畫,向國際社會回應善意,並分享台灣創新的顱顏醫療技術和經驗。
COVID-19疫情期間,台灣看到國際間互助互惠的情誼,相繼有美國、日本、立陶宛、斯洛伐克、捷克及波蘭等六國捐贈疫苗,我們也希望向世界傳達善的力量,間接幫助世界各地顱顏異常的家庭,並與相對友善國家深化醫療合作關係。
唇顎裂國際研修醫師歷程
2018年1月,各國的研究醫師前往臺北醫學大學附設醫院向陳國鼎醫師學習唇顎裂手術及相關知識。
照片左起為:Dorte Ohrmann(德國)、陳國鼎醫師、April LS Wong(馬來西亞)、 Paa Ekow Hoyte-Williams(迦納)
2019年12月,義大利醫師帶著科內年輕醫師前來短期學習唇顎裂手術及相關知識。
照片左二為:義大利米蘭 Dr Autelitano醫師
2023 國際唇顎裂研修醫師訓練計畫
森田皓貴醫師結訓影片
唇顎裂產前診斷與產後治療團隊
台兒胎兒唇顎裂聯合門診實況:匯集胎兒唇顎裂專長的婦產科醫師、顱顏外科醫師、 臨床協調師、專門的超音波技術員和個管師,為懷有唇顎裂胎兒的孕婦進行產前診斷和諮詢。
一排:楊子逸醫師;二排左起:陳國鼎醫師、李文車醫師;三排左起:蔡宛祐協調師、 王儒萱護理師、李佳恆放射師。
臺北醫學大學附設醫院顱顏中心團隊合照。
一排左起:鍾麗英護理長、黃郁理醫師、陳國鼎醫師、蔡宛祐協調師、朱欣蘭護理長;二排左起:施潔瑜副主任、李佳穎護理師、潘禕琳專科護理師、Lucia Pannuto 醫師、 朱詠琳專科護理師、李昕緯護理師、王虹文研究助理。
臺北醫學大學附設醫院顱顏中心團隊、與台兒診所胎兒顱顏畸形工作小組,雙方於 2020 年「第 12 屆台兒胎兒醫學工作坊」會場合影。
一排左起:李佳恆放射師、黃宇鋭醫師、陳國鼎醫師、李琇菁語言治療師、陳姵璇醫師、 蔡宛祐協調師、潘禕琳護理師、林哲玄醫師;二排左起:蘇婉婷放射師、張東曜醫師、楊子逸醫師、李文車醫師、王儒萱護理師、 葛萱放射師。
台兒診所
楊子逸醫師
楊子逸醫師
南投埔里基督教醫院
李文車醫師
李文車醫師
台兒診所
王儒萱護理師
王儒萱護理師
台兒診所
李佳恆放射師
李佳恆放射師
台兒診所
夏敬淇放射師
夏敬淇放射師
唇顎裂父母支持工作坊
由陳國鼎醫師親自帶領唇顎裂胎兒的準爸媽們
一同參與兔寶兒父母成長工作坊
透過個人生命經驗回顧、志工媽媽經驗交流、醫護諮詢及照顧技巧分享等議題
協助孕婦及家屬降低產前焦慮
提供日後更高品質的照護
陪伴家屬一起迎接兔寶兒
胎兒唇顎裂產前到產後照護認證課程
面對唇顎裂的新生兒
讓人難受的是月子中心或保姆系統因照護能力不足
而拒絕唇顎裂寶寶照顧服務
台灣胎兒醫學振興會與陳國鼎醫師特別開設此課程
讓專業照護人力(產後護理之家的護理人員、保母)增加對唇顎裂的知能
進而熟悉如何照護唇顎裂寶寶
也提供給兔寶爸媽輪替和喘息的機會
台北建成扶輪社職業服務參訪
(2021年12月1日)
(圖左)來自義大利的 Lucia Pannuto 研習醫師
於2020年11月前來台灣向陳國鼎醫師學習唇顎裂相關知識
唇顎裂產後照護相關書籍
小兔兒要長大-唇顎裂療癒手冊
出版日期:2020/09
監修 :陳國鼎、張東曜、李文車
作者:楊子逸、陳彥妮、李佳恆、蘇婉婷、王儒萱
這是全台第一本以圖文並茂的形式,來介紹唇顎裂各類型及治療的參考手冊,讓爸媽們在產前及產後,更容易理解寶寶出生後的外觀、照護及治療時程。
▶ 紙本購買請洽本會
唇顎裂產後攻略集顎裂療癒手冊
預計出版日期:2022/01
監修 :陳國鼎、張東曜
製作團隊:
台兒診所胎兒顱顏畸型形工作小組(楊子逸醫師、王儒萱護理師)
臺北醫學大學附設醫院顱顏中心醫療團隊(陳國鼎醫師、潘禕琳護理師、蔡曉倩醫師、陳中明醫師、林哲玄醫師、陳姵璇醫師、李琇菁語言治療師、曾頌惠醫師、黃宇鋭醫師、蔡宛祐協調師)
這是每個撫育唇顎裂孩子的家庭,都需要的一本書。專為唇顎裂家庭設計,從產前診斷到產後治療,常見問題、完整匯集!
相關新聞連結
林靜儀北上媒合國際醫療訓練合作王定宇盼她「早日歸隊」
計畫主持人
陳國鼎
Philip Kuo-Ting Chen M.D.
臺北醫學大學附設醫院顱顏中心主任
E-mail: philip.ktchen@gmail.com
學經歷:
1974-1981 國立台灣大學醫學系學系
醫學專長:
顱顏重建
唇顎裂
正顎手術
兒童整形
整形美容
自體脂肪移植
產業經歷:
July 1980 – June 1981 Internship, National Taiwan University Hospital
July 1981 – June 1984 Residency in General Surgery, Veterans General Hospital, Taipei
July 1984 – June 1986 Residency in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1986 – June 1987 Senior Resident in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1987 – June 1990 Attending Staff in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
July 1990 – June 1991 Clinical Fellow in Craniofacial Surgery, Hospital for Sick Children & University of Toronto, Toronto, Canada
July 1991 – April 1996 Attending Staff in Plastic Surgery,Craniofacial Surgery & Pediatric Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Feb 1992 – July 1993 Instructor in Surgery, Chang Gung Memorial Hospital
July 1993 – July 1997 Assistant Professor in Surgery, Chang Gung Memorial Hospital
April 1996 – Aug 2002 Director of Pediatric Plastic Surgery, Chang Gung Children's Hospital, Taoyuan, Taiwan
July 1997 – July 2011 Associate Professor in Surgery, Chang Gung Memorial Hospital
Aug 1997 – July 2003 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei
Apr 2000 – July 2006 Deputy-chief in surgery, Chang Gung Children’s Hospital, Taoyuan
Nov 1998 – Nov 2006 Council member in the Asian Pacific Craniofacial Association
Jan 2001 – Feb 2007 President, Taiwan Cleft Palate-Craniofacial Association
Nov 2003 – July 2007 Vice Chairman, Department of Plastic & Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei
Dec 2004 – Nov 2008 Council member, Plastic Surgery Association, ROC
Nov 2006 – Oct 2008 President, Asian Pacific Craniofacial Association
Dec 2006 – Dec 2010 Council member, Taiwan Society of Aesthetic & Plastic Surgery
May 2006 – May 2014 National secretary for Chinese Taipei in International Society of Aesthetic Plastic Surgery
July 2006 – June 2014 Director of Craniofacial Surgery in Plastic Surgery, Chang Gung Memorial Hospital, Taipei & Taoyuan
Aug 2011 – June 2017 Board member, Asian Pacific Region, AOCMF
July 2011 – Sep 2017 Professor in Surgery, Chang Gung Memorial Hospital
Jan 2012 – Sep 2017 Director, Craniofacial center, Chang Gung Memorial Hospital, Taoyuan
Jun 2007 – May 2019 Medical Advisory Board, The Smile Train
專科學會:
Surgical Association, Taiwan.
Plastic Surgery Association, Taiwan.
Taiwan Cleft Palate-Craniofacial Association
American Cleft Palate-Craniofacial Anomaly Association
Taiwan Society of Aesthetic & Plastic Surgery
Asian Pacific Craniofacial Surgical Association
學術研究:
1.NSC88-2314-B-182A-016, 1998-1999 – An animal Model in Experimental Studies of Maxillary Growth after Palatoplasty under Microscopic Magnification.
2.CMRP774 – The Effect of the Residual Alveolar Cleft on the Nasal Structure and Physiology in Cleft Patients.
3.NSC89-2314-B-182-098 – Assessment of Lip Function after Lip Repair (Co-investigator)
4.NSC90-2320-B-182A-00, 2001-2003 – Genetic epidemiologic study on oral clefts by association and transmission disequilibrium test in Taiwan. (Co-investigator)
5.NSC90-2212-E-008-025, 2001-2002 – A computer-assisted simulation, planning and navigation system for craniofacial reconstructive and plastic surgery. (Co-investigator)
6.NSC90-2212-E-182A-001, 2001-2003 – The design and fabrication of defect implants, planning and simulation of craniofacial reconstruction.
7.NSC91-2314-B-182A-119, 2002-2003 – Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial
8.NSC92-2314-B-182A-173, 2003-2004 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (1)
9.NSC93-2314-B-182A-020,2004-2005 -- Alveolar bone grafting by tissue engineering. Preliminary study before clinical trial by large animal (2)
10.NSC95-2314-B-182A-043, 2006-2007 – Sensory recovery after facial bone injury
11.NIH grant R01 DE014581-01A1, 2004-2008 – International genetic epidemiology of oral clefts. (Co-investigator)
12.SMRPG34002, 2004-2006 – Clinical manifestation and biomedical study on neurofibromatosis. (Co-investigator)
13.SQCP01 – A controlled randomized study for the speech and growth outcome between two different timing and techniques of cleft palate repair.
14.CMRPG390731, 2010-2013 – Botulinum toxin to improve results in cleft lip repair
15.CMRPG390721, 2010-2013 -- Long term comparison of two nasoalveolar molding techniques in complete unilateral cleft lip patients
16.CMRPG590011, 2010-2013 -- Morphological change of chest wall after harvesting the costal cartilage. (Co-investigator)
17.CMRPG5C0111, 2013-2014 -- Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial. (Co-investigator)
18. CMRPG5C0101, 2013-2014 -- The establishment of an integrated database on oral clefts. (Co-investigator)
19.CMRPG5C0121, 2013-2014 -- Stability of One-piece versus Two-piece Le Fort I Osteotomy: A Prospective Study. (Co-investigator)
20. CRRPG5C0131, 2013-2014 -- Comparative Outcomes of Alveolar Bone Grafting versus Gingivoperiosteoplasty at the Time of Le Fort I Osteotomy: A Prospective Randomized Trial. (Co-investigator)
21.CRRPG5C0141, 2013-2014 -- Inferior Alveolar Nerve Injury after Bilateral Sagittal Split Osteotomy in Oral Clefts. (Co-investigator)
22.CRRPG5C0071, 2014-2016 -- The impacts of Orthognathic Surgery on Speech and Velopharyngeal function of patients with Cleft Lip and Palate.
23. CRRPG5C0061, 2014-2016 -- Using clinical audiology to seek for related hearing changes following Orthognathic surgery in cleft patients. (Co-investigator)
24. CRRPG5C0051, 2014-2016 -- Airway Changes after Cleft Orthognathic Surgery Evaluated by Three Dimensional Computed Tomography and Overnight Polysomnographic Study. (Co-investigator)
25. CRRPG5C0041, 2014-2016 -- The changes of periodontal tissues following orthognathic surgery in patients with unilateral cleft lip and palate. (Co-investigator)
26. CRRPG5C0031, 2014-2016 -- Post Operative Stability of Surgery First or Orthodontic First in Unilateral Cleft lip and Palate. (Co-investigator)
27. XMRPG1E0091, 2015-2016 -- BOTOX Treatment of Masseter Muscle Hypertrophy.
28. CMRPG5E0061, 2015-2016 -- Clinical evaluation of silicone gel in the treatment of cleft lip scars.(Co-investigator)
29. CMRPG5F0021, 2015-2016 -- The Use of New Designed Nasal Splint in the Primary Management of Unilateral Cleft Nasal Deformity.(Co-investigator)
30. CMRPG5F0061, 2016 – Craniofacial Risk Factors of Obstrctive Sleep Apnea Following Pharyngeal Flap for Secondary Velopharyngeal Insufficiency. (Co-investigator)
31. CMRPG3F0731, 2016-2017 -- The Effect of Botulinum Toxin to unilateral cleft lip scar and nostril width.
32. NMRPG5F0051, 2016-2017 – Long Term Comparison Study of Philtral Ridge Morphology with Two Different Techniques of Philtral Reconstruction. (Co-investigator)
33. NMRPG3F0471, 2016-2017 -- Botulinum Toxin for the prevention of widening of unilateral cleft lip nose.
34. 1789-301-008, 2019-2021 -- BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
35. 109-2314-B-038-035-, 110-2314-B-038 -168 -, 2020-2022 -- The evaluation and treatment of nasal obstruction in unilateral cleft lip and palate patients.
特殊榮譽:
est paper award: Philip KT Chen, J Wu, YR Chen, MS Noordhoff: Correction of secondary velopharyngeal insufficiency in cleft palate patients with Furlow palatoplasty. Plast Reconstr Surg 94:933, 1994. Best paper award for the American Society of Maxillofacial Surgery, 1995
Best paper award: Eric JW Liou, Philip KT Chen, CS Huang, YR Chen: Interdental Distraction Osteogenesis and Rapid Tooth Movement: A Novel Approach to Approximate a Wide Alveolar Cleft or Bony Defect: Plast Reconstr Surg 105(4): 1262, 2000. Best paper award for the American Society of Maxillofacial Surgery, 2001
Visiting expertise in the Expertise Course of Hong Kong Plastic Surgery Society. Hong Kong, Jan, 2001.
Visiting expertise for the Great Ormond Street Hospital for Children, Nov, 2003
“Millard’s Visiting Professor Oration” in 4th Annual Congress of the Indian Society of Cleft Lip, Palate and Craniofacial Anomalies, Hyderabad, India, 2005
Visiting professor, Jiaotung University, Xian, China, Apr, 2009
“Godrej visiting professor oration”. In Annual meeting of the Association of Plastic surgeons of India, Chandigarh, India, 2014
Best paper award: CS Chang, CG Wallace, YC Hsiao, CJ Chang, PKT Chen: Botulinum Toxin to Improve Results in Cleft Lip Repair. Plast Reconstr Surg 134(3):511-516, 2014 (Corresponding author). PRS best paper award 2015.
“Best International Collaboration Paper-Gold, 2016” (PRS Global Open 3(3);e313, 2015: A Model Humanitarian Cleft Mission: 312 cleft surgeries in 7 days. GQ Fayyaz, NA Gill, I Ishaq, MA Ganatra, F Mahmood, M Kashif, I Alam, P KT Chen, LJ Lo, DR Laub)
張東曜
Tung-yao Chang
台兒診所創辦人、院長
E-mail : tychang@fetalmedicine.tw
學經歷:
1995-1992 臺北醫學大學附設醫院醫學系學士
1998-1999 英國諾丁漢大學人類發展學院產科超音波學碩士
醫學專長:
高危險妊娠
胎兒超音波
產業經驗:
1994-1998 馬偕紀念醫院婦產科住院醫師
1998-1999 英國國王學院附設醫院胎兒醫學中心研究員
2001年 馬偕醫院妊娠評估中心創辦人、台北馬偕醫院婦產部高危險妊娠科主治醫師
2008年 創立台兒診所
學術研究:
Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Chen CP, Chern SR, Shih JC, Wang W, Yeh LF, Chang TY, Tzen CY. Prenat Diagn. 2001 Feb;21(2):89-95.
Prenatal diagnosis of de novo distal 11q deletion associated with sonographic findings of unilateral duplex renal system, pyelectasis and orofacial clefts. Chen CP, Chern SR, Tzen CY, Lee MS, Pan CW, Chang TY, Wang W. Prenat Diagn. 2001 Apr;21(4):317-20.
Prenatal diagnosis of partial monosomy 18p(18p11.2-->pter) and trisomy 21q(21q22.3-- >qter) with alobar holoprosencephaly and premaxillary agenesis. Chen CP, Chern SR, Wang W, Lee CC, Chen WL, Chen LF, Chang TY, Tzen CY. Prenat Diagn. 2001 May; 21(5):346-50. Review.
Resolution of fetal bilateral chylothorax and ascites after two unilateral thoracocenteses. Chen CP, Chang TY, Wang W. Ultrasound Obstet Gynecol. 2001 Oct;18(4):401-2.
Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome. Chen CP, Sheu JC, Wang W, Lin SP, Chang TY, Tzen CY. Prenat Diagn. 2002 Feb;22(2):166.
Sonographic appearance of the uterus after simple square suturing for rapid control of postpartum hemorrhage and preservation of fertility. Chen CP, Chang TY, Yeh LF, Lin CJ, Wang W. J Clin Ultrasound. 2002 Mar-Apr;30(3):189-91.
Sonographic detection of situs inversus, ventricular septal defect, and short-rib polydacty-ly syndrome type III (Verma-Naumoff) in a second-trimester fetus not known to be at risk. Chen CP, Chang TY, Tzen CY, Lin CJ, Wang W. Ultrasound Obstet Gynecol. 2002 Jun;19(6):629-31.
Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb- body wall complex. Chen CP, Tzen CY, Chang TY, Yeh LF, Wang W. Ultrasound Obstet Gynecol. 2002 Jul;20(1):94-5.
Second trimester molecular diagnosis of a stop codon FGFR3 mutation in a type I thanatophoric dysplasia fetus following abnormal ultrasound findings. Chen CP, Chern SR, Chang TY, Lin CJ, Wang W, Tzen CY. Prenat Diagn. 2002 Aug;22(8):736-7.
Perinatal imaging findings of inherited Sotos syndrome. Chen CP, Lin SP, Chang TY, Chiu NC, Shih SL, Lin CJ, Wang W, Hsu HC. Prenat Diagn. 2002 Oct;22(10):887-92.
Prenatal diagnosis of partial trisomy 3p and partial monosomy 11q in a fetus with a Dandy-Walker variant and trigonocephaly. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Town DD, Chen LF, Lee MS. Prenat Diagn. 2002 Dec;22(12):1112-3.
Prenatal diagnosis of the Dandy-Walker malformation and ventriculomegaly associated with partial trisomy 9p and distal 12p deletion. Chen CP, Chang TY, Shih JC, Lin SP, Lin CJ, Wang W, Lee CC, Town DD, Pan CW, Tzen CY. Prenat Diagn. 2002 Dec;22(12): 1063-6.
Prenatal diagnosis of mosaic ring chromosome 22 associated with cardiovascular abnor- malities and intrauterine growth restriction. Chen CP, Chern SR, Chang TY, Lee CC, Chen LF, Tzen CY, Wang W, Lin CJ, Yang BP, Yang LS. Prenat Diagn. 2003 Jan;23(1): 40-3.
Prenatal diagnosis of de novo mosaic distal 18q deletion associated with congenital anomalies. Chen CP, Tzen CY, Chang TY, Lin CJ, Wang W, Lee CC, Chen LF, Chen WL. Ultrasound Obstet Gynecol. 2003 Feb;21(2):202-4.
Second-trimester sonographic detection of short rib-polydactyly syndrome type II (Majewski) following an abnormal maternal serum biochemical screening result. Chen CP, Chang TY, Tzen CY, Wang W. Prenat Diagn. 2003 Apr;23(4):353-5.
Early second-trimester diagnosis of monozygotic twins discordant for cystic hygroma col- li and Turner syndrome. Chen CP, Chang TY, Chern SR, Town DD, Pan CW, Lee MS, Wang W. Prenat Diagn. 2003 Apr;23(4):352-3.
Second-trimester sonographic demonstration of retrognathia and bilateral pyelectasis in a fetus with a duplication of chromosome 10q24.1—>qter. Chen CP, Chang TY, Tzen CY, Wang W, Lee CC, Chen LF, Lee MS, Lin SP. Ultrasound Obstet Gynecol. 2003 May; 21(5):516-8.
Prenatal diagnosis of de novo terminal deletion of chromosome 7q. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Lee MS, Wang W. Prenat Diagn. 2003 May; 23(5):375-9.
Prenatal diagnosis of otocephaly with microphthalmia/anophthalmia using ultrasound and magnetic resonance imaging. Chen CP, Wang KG, Huang JK, Chang TY, Lin YH, Chin DT, Tzen CY, Wang W. Ultrasound Obstet Gynecol. 2003 Aug;22(2):214-5.
Prenatal diagnosis of choledochal cyst using ultrasound and magnetic resonance imaging. Chen CP, Cheng SJ, Chang TY, Yeh LF, Lin YH, Wang W. Ultrasound Obstet Gynecol. 2004 Jan;23(1):93-4.
Prenatal diagnosis of mosaic distal 5p deletion and review of the literature. Chen CP, Lee CC, Chang TY, Town DD, Wang W. Prenat Diagn. 2004 Jan;24(1):50-7. Review.
Clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 4. Chen CP, Chern SR, Lee CC, Chang TY, Wang W, Tzen CY. Prenat Diagn. 2004 Jan; 24(1):38-44. Review.
Prenatal diagnosis of the distal 11q deletion and review of the literature. Chen CP, Chern SR, Chang TY, Tzen CY, Lee CC, Chen WL, Chen LF, Wang W. Prenat Diagn. 2004 Feb; 24(2):130-6. Review.
Partial trisomy 10 (10q11.2-->pter) and partial trisomy 18 (18p11.2-->pter) associated with abnormal sonographic findings and a maternal serum screen-positive result. Chen CP, Chang TY, Town DD, Chen LF, Pan CW, Wang W, Tzen CY. Ultrasound Obstet Gy- necol. 2004 Feb;23(2):202-4. Review.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Second-trimester nasal bone hypoplasia/aplasia associated with cleidocranial dysplasia. Chen CP, Hung HY, Chang TY, Lin SP, Wang W. Prenat Diagn. 2004 May;24(5):399-400.
Prenatal identification of fetal overgrowth, abdominal wall defect, and neural tube defect in pregnancies achieved by assisted reproductive technology. Chen CP, Lin SP, Hwu YM, Chang TY, Wang W. Prenat Diagn. 2004 May;24(5):396-8.
Prenatal sonographic diagnosis of acrania associated with amniotic bands. Chen CP, Chang TY, Lin YH, Wang W. J Clin Ultrasound. 2004 Jun;32(5):256-60.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Prenatal diagnosis of mosaic 22q11.2 microdeletion. Chen CP, Chern SR, Lee CC, Lin SP, Chang TY, Wang W. Prenat Diagn. 2004 Aug;24(8):660-2.
Molecular genetic analysis of the TSC genes in two families with prenatally diagnosed rhabdomyomas. Chen CP, Su YN, Hung CC, Lee CN, Hsieh FJ, Chang TY, Chen MR, Wang W. Prenat Diagn. 2005 Feb;25(2):176-8.
Recurrent fetal pyelectasis in a family with fetuses associated with partial trisomy 10q (10q24.1—>qter). Chen CP, Chang TY, Tzen CY, Wang W, Lee CC. Prenat Diagn. 2005 Mar;25(3):263-4.
Prenatal magnetic resonance imaging of Galloway-Mowat syndrome. Chen CP, Chang TY, Lin SP, Huang JK, Tsai JD, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):525-7.
Contribution of ultrafast magnetic resonance imaging in prenatal diagnosis of sonograph- ically undetected cerebral tuberous sclerosis associated with cardiac rhabdomyomas. Chen CP, Liu YP, Huang JK, Chang TY, Chen MR, Chiu NC, Wang W. Prenat Diagn. 2005 Jun;25(6):523-4.
Prenatal diagnosis, sonographic findings and molecular genetic analysis of a 46,XX/ 46,XY true hermaphrodite chimera. Chen CP, Chern SR, Sheu JC, Lin SP, Hsu CY, Chang TY, Lee CC, Wang W, Chen HE. Prenat Diagn. 2005 Jun;25(6):502-6.
Prenatal diagnosis of an acardiac amorphous twin and the anomalous co-twin in a monoamniotic twin pregnancy. Chen CP, Shih JC, Chang TY, Chern SR, Lin CY, Wang W, Tzen CY. Prenat Diagn. 2005 Jul;25(7):618-20.
Prenatal magnetic resonance imaging demonstration of the systemic feeding artery of a pulmonary sequestration associated with in utero regression. Chen CP, Liu YP, Lin SP, Sheu JC, Hsu CY, Chang TY, Wang W. Prenat Diagn. 2005 Aug;25(8):721-3.
Prenatal diagnosis of partial trisomy 10q (10q25.3-->qter) and partial monosomy 18q (18q23—>qter). Chen CP, Chern SR, Chang TY, Lee CC, Chen WL, Wang W. Prenat Di- agn. 2005 Nov;25(11):1069-71.
Prenatal diagnosis of the supernumerary der(22)t(11;22) syndrome associated with ab- normal sonographic findings. Chen CP, Wang TH, Chang TY, Lee CC, Chen WL, Chen
LF, Wang W. Genet Couns. 2006;17(4):469-72.
Prenatal two- and three-dimensional ultrasound diagnosis of limb reduction defects associated with homozygous alpha-thalassemia. Chen CP, Chang TY, Su YN, Hsu CY, Wang W. Fetal Diagn Ther. 2006;21(4):374-9. Review.
Recurrent Galloway Mowat syndrome associated with abnormal prenatal sonographic findings. Chen CP, Lin SP, Chang TY, Tsai JD, Huang JK, Wang W. Genet Couns. 2006;17(1):87-9.
Prenatal diagnosis of pure distal 18q deletion. Chen CP, Chern SR, Hung FY, Hsu CY, Chang TY, Lee CC, Town DD, Chen WL, Chen LF, Tzen CY, Wang W, Ma R. Prenat Diagn. 2006 Feb;26(2):184-5.
Prenatal diagnosis of a micropenis in a male fetus with partial trisomy 12q (12q24.32-- >qter) and partial monosomy 21q (21q22.2—>ter-->qter). Chen CP, Lin CC, Chang TY, Li YC, Hsieh LJ, Lee CC, Chen LF, Wang W. Prenat Diagn. 2006 Aug;26(8):757-9.
Second-trimester diagnosis of limb-body wall complex with literature review of patho-
genesis. Chen CP, Lin CJ, Chang TY, Hsu CY, Tzen CY, Wang W. Genet Couns. 2007;18(1):105-12.
Preliminary descriptive statistics of the Taiwanese Registry of Epilepsy and Pregnancy for
the first 2 years. Chang TY, Lai CW, Yu HY, Hsu JJ, Shih YH, Chen CP; Taiwanese Reg-
istry of Epilepsy and Pregnancy. Taiwan J Obstet Gynecol. 2007 Mar;46(1):47-9.
Prenatal diagnosis of the hypoplastic right heart syndrome with sex chromosome penta-
somy (49,XXXXY). Chen CP, Lin CJ, Chang TY, Chern SR, Tzen CY, Chen WL, Wang W. Prenat Diagn. 2007 Mar;27(3):285-6.
Prenatal diagnosis of low-level mosaic tetrasomy 9p by amniocentesis. Chen CP, Chang
TY, Chern SR, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2007 Apr;27(4):383-
5.
Early second-trimester diagnosis of fetal otocephaly. Chen CP, Chang TY, Huang JK,
Wang W. Ultrasound Obstet Gynecol. 2007 Apr;29(4):470-1.
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP, Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal magnetic resonance imaging evaluation of a digynic triploid fetus. Chen CP, Chang TY, Liu YP, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):284-5
Third-trimester 3D ultrasound evaluation of thanatophoric dysplasia type I. Chen CP,
Chang TY, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2007 Sep;46(3):281-3.
Prenatal sonographic findings of Klippel-Trénaunay-Weber syndrome. Chen CP, Lin SP,
Chang TY, Lee HC, Hung HY, Lin HY, Huang JP, Wang W. J Clin Ultrasound. 2007 Sep;
35(7):409-12.
Prenatal diagnosis of Fryns syndrome associated with a microdeletion at 8p23.1. Chen CP, Wang TH, Chen YJ, Chang TY, Liu YP, Tzen CY, Chern SR, Wang W. Prenat Diagn.
2007 Oct;27(10):967-9.
Abnormal prenatal hematological findings in congenital leukemia of Down syndrome with hepatosplenomegaly. Chen CP, Lin SP, Chang TY, Ho HT. Prenat Diagn. 2007 Dec; 27(13):1266-7.
Concomitant omphalocele and anencephaly associated with trisomy 18 and arthrogryposis diagnosed in early pregnancy. Chen CP, Chang TY, Lin HH, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):93-4.
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. Chen CP, Chang TY, Hung JH, Chen CY, Wang W. Taiwan J Obstet Gynecol. 2008 Mar;47(1):91-2.
Prenatal evaluation with magnetic resonance imaging of a giant blind ectopic ureter asso-ciated with a duplex kidney. Chen CP, Liu YP, Huang JP, Chang TY, Tsai FJ, Tsai JD,Sheu JC, Wang W. Ultrasound Obstet Gynecol. 2008 Mar;31(3):360-2.
Prenatal diagnosis of concomitant Wolf-Hirschhorn syndrome and split hand-foot mal- formation associated with partial monosomy 4p (4p16.1-->pter) and partial trisomy 10q (10q25.1—>qter). Chen CP, Chen YJ, Chern SR, Tsai FJ, Chang TY, Lee CC, Town DD, Lee MS, Wang W. Prenat Diagn. 2008 May;28(5):450-3.
Prenatal 3-dimensional sonographic and MRI findings in omphalocele-exstrophy- imperforate anus-spinal defects complex. Chen CP, Chang TY, Liu YP, Tsai FJ, Chien SC,
Tsao CM, Yang HB, Wang W. J Clin Ultrasound. 2008 Jun;36(5):308-11.
Prenatal diagnosis of 46,XX,DER(13;21)(Q10;Q10),+21 and transient abnormal myelopoiesis in a fetus with hepatosplenomegaly and spontaneous resolution of fetal ascites. Chen CP, Tsai FJ, Chern SR, Chang TY, Hsu CY, Lin HH, Wang W. Taiwan J Obstet Gynecol. 2009 Mar;48(1):84-7.
Prenatal magnetic resonance imaging, ultrasound imaging findings and genetic analysis of concomitant rhabdomyomas and cerebral tuberous sclerosis. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Sep;48(3):327-31.
22q11.2 microdeletion in a fetus with double-outlet right ventricle, pulmonary stenosis and a ventricular septal defect: prenatal diagnosis by array comparative genomic hybridization. Chen CP, Su YN, Chang TY, Chern SR, Tsai FJ, Hwang JK, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):437-40.
Prenatal diagnosis of monosomy 17p (17p13.3—>pter) associated with polyhydramnios, intrauterine growth restriction, ventriculomegaly, and Miller-Dieker lissencephaly syndrome in a fetus. Lin CY, Chen CP, Liau CL, Su PH, Tsao TF, Chang TY, Wang W. Taiwan J Obstet Gynecol. 2009 Dec;48(4):408-11.
Prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the TSC2 gene. Chen CP, Su YN, Chang TY, Liu YP, Tsai FJ, Chen MR, Hwang JK, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep;49(3):387-9.
Prenatal diagnosis of persistent cloaca with hydrometrocolpos and ascites by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy. Chen CP, Liu YP, Chang TY, Tsai FJ, Chen CY, Wu PC, Chen TH, Wang W. Taiwan J Obstet Gynecol. 2010 Sep; 49(3):385-6.
The changing face of early-onset neonatal sepsis after the implementation of a maternal group B Streptococcus screening and intrapartum prophylaxis policy--a study in one medical center. Lin CY, Hsu CH, Huang FY, Chang JH, Hung HY, Kao HA, Peng CC, Jim WT, Chi H, Chiu NC, Chang TY, Chen CY, Chen CP. Pediatr Neonatol. 2011 Apr; 52(2):78-84.
Short rib-polydactyly syndrome type II (Majewski): prenatal diagnosis, perinatal imaging findings and molecular analysis of the NEK1 gene. Chen CP, Chang TY, Chen CY, Wang TY, Tsai FJ, Wu PC, Chern SR, Wang W. Taiwan J Obstet Gynecol. 2012 Mar;51(1):100- 5.
Persistent cloaca presenting with a perineal cyst: Prenatal ultrasound and magnetic resonance imaging findings. Chen CP, Chang TY, Hsu CY, Liu YP, Tsai FJ, Wu PC, Wang W. J Chin Med Assoc. 2012 Apr;75(4):190-3.
Osteogenesis imperfecta type II: prenatal diagnosis and association with increased nuchal translucency and hypoechogenicity of the cranium. Chen CP, Su YN, Chang TY, Huang MC, Pan CH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):315- 8.
Identification of a deletion mutation in the short flanking repeat region of exon 44 of the COL1A1 gene in a fetus with osteogenesis imperfecta type II. Chen CP, Su YN, Chang TY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):308-11.
Osteogenesis imperfecta type I: second-trimester diagnosis and incidental identification of a dominant COL1A1 deletion mutation in the paucisymptomatic father. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun; 51(2):276-9.
Prenatal diagnosis and molecular genetic analysis of short rib-polydactyly syndrome type III (Verma-Naumoff) in a second-trimester fetus with a homozygous splice site mutation in intron 4 in the NEK1 gene. Chen CP, Chern SR, Chang TY, Su YN, Chen YY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2012 Jun;51(2):266-70.
Prenatal diagnosis of ring chromosome 2 with lissencephaly and 2p25.3 and 2q37.3 microdeletions detected using array comparative genomic hybridization. Chen CP, Lin CJ, Chang TY, Chern SR, Wu PS, Chen YT, Su JW, Lee CC, Chen LF, Wang W. Gene. 2013 Apr 25;519(1):164-8.
Rapid detection of de novo P253R mutation in FGFR2 using uncultured amniocytes in a pregnancy affected by polyhydramnios, Blake's pouch cyst, and Apert syndrome. Chen CP, Su YN, Chang TY, Chern SR, Chen CY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Jun;52(2):273-7.
Rapid detection of K650E mutation in FGFR3 using uncultured amniocytes in a pregnan- cy affected with fetal cloverleaf skull, occipital pseudoencephalocele, ventriculomegaly, straight short femurs, and thanatophoric dysplasia type II. Chen CP, Chang TY, Lin MH, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):420-5.
Detection of maternal transmission of a splicing mutation in the TSC2 gene following prenatal diagnosis of fetal cardiac rhabdomyomas mimicking congenital cystic adenoma- toid malformation of the lung and cerebral tubers and awareness of a family history of maternal epilepsy. Chen CP, Chang TY, Guo WY, Su YN, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Sep;52(3):415-9.
Detection of a de novo Y278C mutation in FGFR3 in a pregnancy with severe fetal hypochondroplasia: prenatal diagnosis and literature review. Chen CP, Su YN, Lin TH, Chang TY, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):580-5.
VACTERL association with hydrocephalus in a fetus conceived by in vitro fertilization and embryo transfer. Chen CP, Chang TY, Chen YY, Chern SR, Su JW, Wang W. Taiwan J Obstet Gynecol. 2013 Dec;52(4):575-9.
Chromosome 17p13.3 deletion syndrome: aCGH characterization, prenatal findings and diagnosis, and literature review. Chen CP, Chang TY, Guo WY, Wu PC, Wang LK, Chern SR, Wu PS, Su JW, Chen YT, Chen LF, Wang W. Gene. 2013 Dec 10;532(1):152-9.
Prenatal diagnosis of hypomethylation at KvDMR1 and Beckwith-Wiedemann syndrome in a pregnancy conceived by intracytoplasmic sperm injection and in vitro fertilization and embryo transfer. Chen CP, Su YN, Chen SU, Chang TY, Wu PC, Chern SR, Wu PS, Kuo YL, Wang W. Taiwan J Obstet Gynecol. 2014 Mar;53(1):90-4.
Prenatal diagnosis and molecular cytogenetic characterization of chromosome 22q11.2 deletion syndrome associated with congenital heart defects. Kuo YL, Chen CP, Wang LK, Ko TM, Chang TY, Chern SR, Wu PS, Chen YT, Chang SY. Taiwan J Obstet Gynecol. 2014 Jun;53(2):248-51.
Detection of de novo secondary trisomy 13 due to isochromosome (13q;13q) of paternal origin in a pregnancy with fetal cystic hygroma. Chen CP, Ko TM, Huang MC, Chern SR, Lin TW, Chang TY, Kuo YL, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2015 Feb; 54(1):78-80.
Prenatal diagnosis of chromosome 8p23.1 microdeletion by array comparative genomic hybridization using uncultured amniocytes in a pregnancy associated with fetal partial corpus callosum agenesis and schizencephaly. Chen CP, Peng CR, Chang TY, Guo WY, Chen YN, Wu PS, Town DD, Wang W. Taiwan J Obstet Gynecol. 2015 Dec;54(6):797-8.
Prenatal diagnosis of 22q11.2 deletion syndrome associated with right aortic arch, left ductus arteriosus, cardiomegaly, and pericardial effusion. Chen YN, Chen CP, Ko TM, Wang LK, Wu PC, Chang TY, Wu PS, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2016 Feb;55(1):117-20.
22q13 deletion syndrome in a fetus associated with microtia, hemivertebrae, and congenital heart defects on prenatal ultrasound. Chen CP, Chang TY, Wang LK, Chern SR, Wu PS, Chen YN, Chen SW, Chen WL, Wang W. Taiwan J Obstet Gynecol. 2016 Jun;55(3):455-6.
Prenatal imaging findings of a rapidly involuting congenital hemangioma (RICH) over right flank in a fetus with a favorable outcome. Chen CP, Chen CY, Chang TY, Yang HY, Chen YN, Chen SW, Wang W. Taiwan J Obstet Gynecol. 2016 Oct;55(5):745-747.
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. Chen CP, Wang LK, Wu PC, Chang TY, Chern SR, Wu PS, Chen YN, Chen SW, Lee CC, Yang CW, Wang W. Taiwan J Obstet Gynecol. 2017 Feb;56(1):102-105.
Prenatal diagnosis of persistent left superior vena cava is associated with coarctation of the aorta e A case report. Wen TM, Huang YL, Wu PC, Li YY, Chen MR, Chang TY. Journal of Medical Ultrasound , Volume 25, Issue 4, December 2017, Pages 244-247.
Antiepileptic drug use among women from the Taiwanese Registry of Epilepsy and Preg- nancy: Obstetric complications and fetal malformation outcomes. Yeh CC, Lussier EC, Sun YT, Lan TY, Yu HY, Chang TY. PLoS One. 2017 Dec 18;12(12):e0189497..
Ultrasound screening for developmental dysplasia of the hip after 4 weeks increases exam accuracy and decreases follow-up visits. Lussier EC, Sun YT, Chen HW, Chang TY, Chang CH. Pediatr Neonatol. 2018 Jul 26. pii: S1875-9572(17)30775-1.
Prenatal diagnosis of coarctation of the aorta with ventricular septal defect: A case report. Huang YL, Hsu KH, Enkhzaya Chuluunbaatar, Wen TM, Li YY, Chen MR, Chang CI, Chang TY. Taiwanese Journal of Obstetrics and Gynecology Volume 57, Issue 6, December 2018, Pages 885-889.
Olisova K, Sung CY, Li YY, Hsia CC, Chang TY. One size fits all? A call to establish Taiwanese fetal growth standards. Taiwan J Obstet Gynecol. 2020;59(3):468.
Lussier, E. , Lei, W. , Sun, Y. , Chen, H. , Chang, T. and Chang, C. (2020) Newborn Hip Screenings at 4 to 8 Weeks Are Optimal in Predicting Referral and Treatment Outcomes: A Retrospective Review. Open Journal of Pediatrics, 10, 332-346.
Lussier EC, Yeh SJ, Chih WL, Lin SM, Chou YC, et al. (2020) Reference ranges and Z-scores for fetal cardiac measurements from two-dimensional echocardiography in Asian population. PLOS ONE 15(6): e0233179.
Ko, H., Chang, TY., Lussier, E.C. et al. Multidisciplinary team approach to the prenatal management of orofacial clefts: a single center cohort study in Taiwan. Sci Rep 10, 13916 (2020).
Huang YS, Lussier EC, Olisova K, Chang YC, Ko H, Chang TY. Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair - Eleven years' experiences. Taiwan J Obstet Gynecol. 2021;60(2):281-289.
Harris RC, Fries MH, Boyle A, et al. Multidisciplinary management of pregnancy in complex congenital heart disease: a model for coordination of care. Congenit Heart Dis. 2014;9(6):E204-E211.
Chou YC, Lussier EC, Olisova K, Chang TY. Age-specific effect of fresh versus frozen embryo transfer on fetal anomalies or intrauterine growth restriction rate. Taiwan J Obstet Gynecol. 2021;60(5):831-835. doi:10.1016/j.tjog.2021.07.009
Olisova K, Sung CY, Lussier EC, Chang TY. Revisions to mid-pregnancy cervical length reference range for preterm birth screening among singleton pregnancies in Taiwan - 10 years' experiences. Taiwan J Obstet Gynecol. 2021;60(5):836-839.
計畫書&申請表格

如有興趣者,請與我們聯絡